Epithelial ingrowth Health Dictionary

Epithelial Ingrowth: From 1 Different Sources


abnormal healing of a corneal wound or incision in which the conjunctival/corneal epithelium invades the internal surface of the healing wound. The consequences of this can be devastating to the eye and difficult to treat.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Carcinoma

A malignant epithelial tumour eventually becoming fatal... carcinoma

Papilloma

Benign epithelial neoplasm in which neoplastic cells cover finger-like processes of dermis. Also anybenign epithelial neoplasm growing outward from an epithelial surface.... papilloma

Epithelium

The layer of cells that covers the entire surface of the body and lines most of the hollow structures within it. Epithelial cells vary in shape according to their function. There are three basic shapes of cell: squamous (thin and flat), cuboidal, and columnar. Most internal organs lined with epithelium are covered with only one layer of cells, but the skin, which is subjected to more trauma, consists of many layers.... epithelium

Allantoin

Prepared synthetically, this powder, which occurs naturally in comfrey root, has been used as an ADJUVANT in the treatment of skin ulcers. It has been thought to stimulate the formation of the surface epithelial layer of skin, but its therapeutic value is now more dubious.... allantoin

Basal Cell Carcinoma

A generally slow growing malignant epithelial tumour, which has potential to invade and metastasise, especially if untreated.... basal cell carcinoma

Benign Prostatic Hypertrophy, Or Hyperplasia

(BPH) The benign buildup in the prostate of “warts” or epithelial neoplasias that can block or interrupt urination, and which are usually concurrent with moderate prostate enlargement. They cause a dull ache on urination, ejaculation, and/or defecation. The diagnosis is medical, since the same subjective conditions can result from cancer of the prostate. BPH is common in men over fifty and can be the result either of diminished production of complete testosterone or poor pelvic circulation. Alcohol, coffee, speed, and antihistamines can all aggravate the problem.... benign prostatic hypertrophy, or hyperplasia

Carcinoma-in-situ

Malignant epithelial tumour showing no invasion.... carcinoma-in-situ

Cystadenoma

Benign tumour of epithelial tissue forming cysts.... cystadenoma

Parotid

A pair of salivary glands tucked into the notch in front of each ear and emptying through parotid ducts by each upper 2nd molar. Although the fluid has some of the thick viscous lubricant nature of saliva from the glands in the floor of the mouth, the parotids secrete high levels of ptyelin and amylase (starch-digesting enzymes) lysozymes (antimicrobial enzymes) and a group of proteins loosely called parotin that stimulate epithelial and nerve cell growth...a lot more here than just spit.... parotid

Scab

The crust which forms on super?cial injured areas. It is composed of FIBRIN, which is exuded from the raw surface, together with blood corpuscles and epithelial cells entangled in its meshes. Healing takes place naturally under this protection, and the scab dries up and falls o? when healing is complete. Scabs appearing on the face without any previous abrasion are usually caused by an infection (see IMPETIGO).... scab

Seronoa Repens

(Bartram) Small.

Synonym: Sabal serrulata (Michaux) Nichols.

Family: Palmae.

Habitat: Southeastern North America.

English: Sabal, Saw Palmetto.

Action: Ripe fruit—diuretic, urinary antiseptic, antiandrogenic, and antiexudative.

The fruit contains fatty acids, especially capric, caproic, caprylic, lau- ric, myristic, oleic, linoleic, linolenic, stearic and palmitic acids; sterols, principally beta-sitosterol and its 3-gluco- side (and fatty acid derivatives), cam- pesterol and stigmasterol; triglycerides; triterpenes; alkanols; polysaccharides; flavonoids; essential oil and anthranilic acid.

Key application: In urination problems due to benign prostatic hyperplasia stages I and II (German Commission E, ESCOP, WHO.) (The lipophilic extracts of Saw Palmetto berries are used in France and Germany for the treatment of BPH. In a study (1999), shrinkage of the epithelial tissue in the transition zone of the prostate has been recorded. (Expanded Commission E Monographs.) (For Clinical studies, see ESCOP.)

In India, Sabal palmetto Lodd. Ex Roem. & Schult (Sabal or Cabbage Palm) is planted in gardens for ornament. The sweet drupes are eaten as such or cooked for preparing a syrup. Other species of Sabal introduced into Indian gardens are: S. mauritiiformis Griseb. & Wendl., S. mexicana Mart., S. umbraculifera Mart., and S. minor Pers. The leaves of S. mexicana contain cyanidin. The leaves of S. minor contain caffeic, p-coumaric and sinapic acids.... seronoa repens

Teeth

Hard organs developed from the mucous membranes of the mouth and embedded in the jawbones, used to bite and grind food and to aid clarity of speech.

Structure Each tooth is composed of enamel, dentine, cement, pulp and periodontal membrane. ENAMEL is the almost translucent material which covers the crown of a tooth. It is the most highly calci?ed material in the body, 96–97 per cent being composed of calci?ed salts. It is arranged from millions of long, six-sided prisms set on end on the dentine (see below), and is thickest over the biting surface of the tooth. With increasing age or the ingestion of abrasive foods the teeth may be worn away on the surface, so that the dentine becomes visible. The outer sides of some teeth may be worn away by bad tooth-brushing technique. DENTINE is a dense yellowish-white material from which the bulk and the basic shape of a tooth are formed. It is like ivory and is harder than bone but softer than enamel. The crown of the tooth is covered by the hard protective enamel and the root is covered by a bone-like substance called cement. Decay can erode dentine faster than enamel (see TEETH, DISORDERS OF – Caries of the teeth). CEMENT or cementum is a thin bone-like material which covers the roots of teeth and helps hold them in the bone. Fibres of the periodontal membrane (see below) are embedded in the cement and the bone. When the gums recede, part of the cement may be exposed and the cells die. Once this has happened, the periodontal membrane can no longer be attached to the tooth and, if su?cient cement is destroyed, the tooth-support will be so weakened that the tooth will become loose. PULP This is the inner core of the tooth and is

composed of a highly vascular, delicate ?brous tissue with many ?ne nerve-?bres. The pulp is very sensitive to temperature variation and to touch. If the pulp becomes exposed it will become infected and usually cannot overcome this. Root-canal treatment or extraction of the tooth may be necessary. PERIODONTAL MEMBRANE This is a layer of ?brous tissue arranged in groups of ?bres which surround and support the root of a tooth in a bone socket. The ?bres are interspersed with blood vessels and nerves. Loss of the membrane leads to loss of the tooth. The membrane can release and re-attach the ?bres to allow the tooth to move when it erupts, or (to correct dental deformities) is being moved by orthodontic springs.

Arrangement and form Teeth are present in most mammals and nearly all have two sets: a temporary or milk set, followed by a permanent or adult set. In some animals, like the toothed whale, all the teeth are similar; but in humans there are four di?erent shapes: incisors, canines (eye-teeth), premolars (bicuspids), and molars. The incisors are chisel-shaped and the canine is pointed. Premolars have two cusps on the crown (one medial to the other) and molars have at least four cusps. They are arranged together in an arch in each jaw and the

cusps of opposing teeth interdigitate. Some herbivores have no upper anterior teeth but use a pad of gum instead. As each arch is symmetrical, the teeth in an upper and lower quadrant can be used to identify the animal. In humans, the quadrants are the same: in other words, in the child there are two incisors, one canine and two molars (total teeth 20); in the adult there are two incisors, one canine, two premolars and three molars (total 32). This mixture of tooth-form suggests that humans are omnivorous. Anatomically the crown of the tooth has mesial and distal surfaces which touch the tooth next to it. The mesial surface is the one nearer to the centre line and the distal is the further away. The biting surface is called the incisal edge for the anterior teeth and the occlusal surface for the posteriors.

Development The ?rst stage in the formation of the teeth is the appearance of a down-growth of EPITHELIUM into the underlying mesoderm. This is the dental lamina, and from it ten smaller swellings in each jaw appear. These become bell-shaped and enclose a part of the mesoderm, the cells of which become specialised and are called the dental papillae. The epithelial cells produce enamel and the dental papilla forms the dentine, cement and pulp. At a ?xed time the teeth start to erupt and a root is formed. Before the deciduous teeth erupt, the permanent teeth form, medial to them. In due course the deciduous roots resorb and the permanent teeth are then able to push the crowns out and erupt themselves. If this process is disturbed, the permanent teeth may be displaced and appear in an abnormal position or be impacted.

Eruption of teeth is in a de?nite order and at a ?xed time, although there may be a few months’ leeway in either direction which is of no signi?cance. Excessive delay is found in some congenital disorders such as CRETINISM. It may also be associated with local abnormalities of the jaws such as cysts, malformed teeth and supernumerary teeth.

The usual order of eruption of deciduous teeth is:

Middle incisors 6–8 months Lateral incisors 8–10 months First molars 12–16 months Canines (eye-teeth) 16–20 months Second molars 20–30 months

The usual order of eruption of permanent teeth is:

First molars 6–7 years Middle incisors 6–8 years Lateral incisors 7–9 years Canines 9–12 years First and second premolars 10–12 years Second molars 11–13 years Third molars (wisdom teeth) 17–21 years

The permanent teeth of the upper (top) and lower (bottom) jaws.

Teeth, Disorders of

Teething, or the process of eruption of the teeth in infants, may be accompanied by irritability, salivation and loss of sleep. The child will tend to rub or touch the painful area. Relief may be obtained in the child by allowing it to chew on a hard object such as a toy or rusk. Mild ANALGESICS may be given if the child is restless and wakens in the night. A serious pitfall is to assume that an infant’s symptoms of ill-health are due to teething, as the cause may be more serious. Fever and ?ts (see SEIZURE) are not due to teething.

Toothache is the pain felt when there is in?ammation of the pulp or periodontal membrane of a tooth (see TEETH – Structure). It can vary in intensity and may be recurring. The commonest cause is caries (see below) when the cavity is close to the pulp. Once the pulp has become infected, this is likely to spread from the apex of the tooth into the bone to form an abscess (gumboil – see below). A lesser but more long-lasting pain is felt when the dentine is unprotected. This can occur when the enamel is lost due to decay or trauma or because the gums have receded. This pain is often associated with temperature-change or sweet foods. Expert dental advice should be sought early, before the decay is extensive. If a large cavity is accessible, temporary relief may be obtained by inserting a small piece of cotton wool soaked, for example, in oil of cloves.

Alveolar abscess, dental abscess or gumboil This is an ABSCESS caused by an infected tooth. It may be present as a large swelling or cause trismus (inability to open the mouth). Treatment is drainage of the PUS, extraction of the tooth and/or ANTIBIOTICS.

Caries of the teeth or dental decay is very common in the more a?uent countries and is most common in children and young adults. Increasing awareness of the causes has resulted in a considerable improvement in dental health, particularly in recent years; this has coincided with a rise in general health. Now more than half of ?ve-year-old children are caries-free and of the others, 10 per cent have half of the remaining carious cavities. Since the start of the National Health Service, the emphasis has been on preventive dentistry, and now edentulous patients are mainly found among the elderly who had their teeth removed before 1948.

The cause of caries is probably acid produced by oral bacteria from dietary carbohydrates, particularly re?ned sugar, and this dissolves part of the enamel; the dentine is eroded more quickly as it is softer (see TEETH – Structure). The exposed smooth surfaces are usually protected as they are easily cleaned during normal eating and by brushing. Irregular and overcrowded teeth are more at risk from decay as they are di?cult to clean. Primitive people who chew coarse foods rarely get caries. Fluoride in the drinking water at about one part per million is associated with a reduction in the caries rate.

Prolonged severe disease in infancy is associated with poor calci?cation of the teeth, making them more vulnerable to decay. As the teeth are formed and partly calci?ed by the time of birth, the diet and health of the mother are also important to the teeth of the child. Pregnant mothers and children should have a good balanced diet with su?cient calcium and vitamin

D. A ?brous diet will also aid cleansing of the teeth and stimulate the circulation in the teeth and jaws. The caries rate can be reduced by regular brushing with a ?uoride toothpaste two or three times per day and certainly before going to sleep. The provision of sweet or sugary juices in an infant’s bottle should be avoided.

Irregularity of the permanent teeth may be due to an abnormality in the growth of the jaws or to the early or late loss of the deciduous set (see TEETH – Development). Most frequently it is due to an imbalance in the size of the teeth and the length of the jaws. Some improvement may take place with age, but many will require the help of an orthodontist (specialist dentist) who can correct many malocclusions by removing a few teeth to allow the others to be moved into a good position by means of springs and elastics on various appliances which are worn in the mouth.

Loosening of the teeth may be due to an accident or in?ammation of the GUM. Teeth loosened by trauma may be replaced and splinted in the socket, even if knocked right out. If the loosening is due to periodontal disease, the prognosis is less favourable.

Discoloration of the teeth may be intrinsic or extrinsic: in other words, the stain may be in the calci?ed structure or stuck on to it. Intrinsic staining may be due to JAUNDICE or the antibiotic tetracycline. Extrinsic stain may be due to tea, co?ee, tobacco, pan (a mixture of chuna and betel nuts wrapped in a leaf), iron-containing medicines or excess ?uoride.

Gingivitis or in?ammation of the gum may occur as an acute or chronic condition. In the acute form it is often part of a general infection of the mouth, and principally occurs in children or young adults – resolving after 10–14 days. The chronic form occurs later in life and tends to be progressive. Various microorganisms may be found on the lesions, including anaerobes. Antiseptic mouthwashes may help, and once the painful stage is past, the gums should be thoroughly cleaned and any calculus removed. In severe conditions an antibiotic may be required.

Periodontal disease is the spread of gingivitis (see above) to involve the periodontal membrane of the tooth; in its ?orid form it used to be called pyorrhoea. In this, the membrane becomes damaged by the in?ammatory process and a space or pocket is formed into which a probe can be easily passed. As the pocket becomes more extensive, the tooth loosens. The loss of the periodontal membrane also leads to the loss of supporting bone. Chronic in?ammation soon occurs and is di?cult to eradicate. Pain is not a feature of the disease but there is often an unpleasant odour (halitosis). The gums bleed easily and there may be DYSPEPSIA. Treatment is largely aimed at stabilising the condition rather than curing it.

Dental abscess is an infection that arises in or around a tooth and spreads to involve the bone. It may occur many years after a blow has killed the pulp of the tooth, or more quickly after caries has reached the pulp. At ?rst the pain may be mild and intermittent but eventually it will become severe and a swelling will develop in the gum over the apex of the tooth. A radiograph of the tooth will show a round clear area at the apex of the tooth. Treatment may be by painting the gum with a mild counter-irritant such as a tincture of aconite and iodine in the early stages, but later root-canal therapy or apicectomy may be required. If a swelling is present, it may need to be drained or the o?ending teeth extracted and antibiotics given.

Injuries to teeth are common. The more minor injuries include crazing and the loss of small chips of enamel, and the major ones include a broken root and avulsion of the entire tooth. A specialist dental opinion should be sought as soon as possible. A tooth that has been knocked out can be re-implanted if it is clean and replaced within a few hours. It will then require splinting in place for 4–6 weeks.

Prevention of dental disease As with other disorders, prevention is better than cure. Children should be taught at an early age to keep their teeth and gums clean and to avoid re?ned sugars between meals. It is better to ?nish a meal with a drink of water rather than a sweetened drink. Fluoride in some of its forms is useful in the reduction of dental caries; in some parts of the UK natural water contains ?uoride, and in some areas where ?uoride content is low, arti?cial ?uoridation of the water supply is carried out. Overcrowding of the teeth, obvious maldevelopment of the jaw and persistent thumbsucking into the teens are all indications for seeking the advice of an orthodontist. Generally, adults have less trouble with decay but more with periodontal disease and, as its onset is insidious, regular dental inspections are desirable.... teeth

Thymoma

A tumour of the THYMUS GLAND. Such tumours are rare and are classi?ed according to the variety of thymus tissue from which they develop. Epithelial thymomas grow slowly and rarely spread. If the tumour arises from LYMPHOID TISSUE, it may progress to a generalised non-Hodgkin’s LYMPHOMA. Another variety is a thymic TERATOMA which is normally benign in women but malignant in men. Thymomas may affect the working of the immune system (see IMMUNITY), increasing the likelihood of infection. They are also associated with MYASTHENIA GRAVIS – an autoimmune disorder; removal of the gland may cure the disorder.... thymoma

Anti-neoplastics

Herbs that prevent formation or destroy tumour cells. Some reported in the literature to arrest the spread of malignancy. A neoplasm is a new growth and may be malignant or non- malignant. Bayberry (intestinal), Bryonia (lung), Clivers (Genito-urinary tract), Comfrey (general), Condurango (gastric), Dandelion (liver), Echinacea, Greater Celandine (epithelial), Mandrake (face and skin), Mistletoe, Myrrh, Plantain (throat), Poke root (breast), Queen’s Delight, Red Clover (epithelial and breast), Rosebay Willowherb (gastric), Vinca rosea (leukaemia), Thuja (womb), Wild Violet (breast and womb), Yellow Dock. ... anti-neoplastics

Cilia

Hair-like filaments on the surface of some epithelial cells (see epithelium).

Cilia are found particularly in the linings of the respiratory tract, where they propel dust and mucus out of the airways.... cilia

Tea For Good Skin

Good skin is something we all want. Even if you’re a man or a woman, black heads or acne are really bothering you. If that is the case, you have definitely tried a lot of pharmaceutical and cosmetic products and nothing seemed to be working. Alternative medicine recommends a number of teas and decoctions that will make your skin smoother than ever. All you have to do is commit to this treatment and maintain an adequate skin hygiene. How Tea for Good Skin Works It’s important to know that not only acne can deteriorate your natural glow. There are also a number of affections that can stain your skin, such as liver or kidney failure, eczema or skin rash due to allergies. Smoke will age you before time, wrinkling your mouth area and your forehead. Also, you may want to change your pillow case more often, in order to keep allergens and microbes away from your face. A Tea for Good Skin’s main purpose is to clear your skin through its antiseptic ingredients and nourish the damaged areas. Efficient Tea for Good Skin When choosing a Tea for Good Skin, you need to pick the ones with the highest antifungal and antiseptic properties. You can either drink the tea or use it as a face cleanser. In case you don’t know which teas are adequate, here’s a list we made for you: - Chamomile Tea – thanks to its antibacterial and antiseptic properties, Chamomile Tea is a great help when it comes to skin treatments. Both the pharmaceutical and the cosmetic companies have included Chamomile on their must have list of ingredients. A cup of tea per day will restore your skin’s natural glow while also improving your general health. - Oolong Tea - contains half the amount of caffeine that other teas contain. You can drink it daily or use it as a compress to apply it on your affected areas. This is probably the most effective Tea for Good Skin and also the safest. If you haven’t tried it yet, now would be a good time! - Black Tea – this wonderful Tea for skin improves your vascular activity and enhances your epithelial cells production. Pay attention, though: don’t take it if you’re on your period or experiencing some menopausal pains in order to avoid complication! - White Tea – also a good nutrient, White Tea can improve your general health, not just your skin. It’s best not to combine it with other tea, though. White Tea can have a negative reaction when mixed with green tea or black tea. You can also use a decoction or White Tea tinctures in order to treat your localized injuries. Tea for Good Skin Side Effects When taken properly, these teas are perfectly safe. Just make sure you don’t exceed the number of cups recommended per day in order to avoid complications such as diarrhea or constipation. Other than that, there’s no reason not to try a face cleanser based on a Tea for Good skin! However, if you’re not sure about it yet, talk to a dermatologist or to an herbalist. Don’t take a Tea for Good Skin if you’re pregnant, breastfeeding, on blood thinners, anticoagulants or preparing for a major surgery. If there’s nothing that could interfere with your herbal treatment, choose a Tea for Good Skin that fits you best and enjoy its wonderful benefits!... tea for good skin

Tissues Of The Body

The simple elements from which the various parts and organs are found to be built. All the body originates from the union of a pair of CELLS, but as growth proceeds the new cells produced from these form tissues of varying character and complexity. It is customary to divide the tissues into ?ve groups:

Epithelial tissues, including the cells covering the skin, those lining the alimentary canal, those forming the secretions of internal organs. (See EPITHELIUM.)

Connective tissues, including ?brous tissue, fat, bone, cartilage. (See under these headings.)

Muscular tissues (see MUSCLE).

Nervous tissues (see NERVE).

Wandering corpuscles of the BLOOD and LYMPH. Many of the organs are formed of a single

one of these tissues, or of one with a very slight admixture of another, such as cartilage, or white ?brous tissue. Other parts of the body that are widely distributed are very simple in structure and consist of two or more simple tissues in varying proportion. Such are blood vessels (see ARTERIES; VEINS), lymphatic vessels (see LYMPHATICS), lymphatic glands (see GLAND), SEROUS MEMBRANES, synovial membranes (see JOINTS), mucous membranes (see MUCOUS MEMBRANE), secreting glands (see GLAND; SALIVARY GLANDS; THYROID GLAND) and SKIN.

The structure of the more complex organs of the body is dealt with under the heading of each organ.... tissues of the body

Adenocarcinoma

n. a malignant epithelial tumour arising from glandular structures, which are constituent parts of most organs of the body. The term is also applied to tumours showing a glandular growth pattern. These tumours may be subclassified according to the substances that they produce, for example mucinous and serous adenocarcinomas, or to the microscopic arrangement of their cells into patterns, for example papillary and follicular adenocarcinomas (see also clear-cell carcinoma). They may be solid or cystic (cystadenocarcinomas).... adenocarcinoma

Adenoma

n. a benign tumour of epithelial origin that is derived from glandular tissue or exhibits clearly defined glandular structures. Adenomas may undergo malignant change (see adenocarcinoma). Some show recognizable tissue elements, such as fibrous tissue (fibroadenomas), while others, such as some bronchial adenomas, may produce active compounds giving rise to clinical syndromes (see carcinoid). Tumours in certain organs, including the pituitary gland, are often classified by their histological staining affinities, for example eosinophil, basophil, and chromophobe adenomas.... adenoma

Carcinosarcoma

n. a malignant tumour of the cervix, uterus, or vagina containing a mixture of *adenocarcinoma and cells with a sarcoma appearance, previously called malignant mixed Müllerian tumours (MMMT). These tumours are actually epithelial in origin and should be treated as high-grade adenocarcinomas. Sarcomatoid differentiation of epithelial cancers often indicates a poor prognosis.... carcinosarcoma

Urtica Dioica

Linn.

Family: Urticaceae.

Habitat: North-western Himalaya from Kashmir to Simla at 2,4003,600 m.

English: Stinging Nettle.

Ayurvedic: Vrishchhiyaa-shaaka (related species).

Unani: Anjuraa.

Folk: Shisuun (Kumaon).

Action: Plant—diuretic, astringent, antihaemorrhagic; eliminates uric acid from the body, detoxifies the blood. Externally, astringent and haemostatic.

Used internally for the treatment of nephritis, haemoptysis and other haemorrhages.

Key application: Above ground parts—as a supportive therapy for rheumatic ailments (internally and externally). Internally, in irrigation therapy for inflammatory diseases of the lower urinary tract and prevention and treatment of kidney gravel. (German Commission E, ESCOP, The British Herbal Compendium, The British Herbal Pharmacopoeia.) Root—in symptomatic treatment of micturition disorders (dysuria, pol- lakiuria, nocturia, urine retention) in benign prostatic hyperplasia at stages I and II. (German Commission E, ESCOP, WHO, The British Herbal Pharmacopoeia.)

Clinical experiments have confirmed the utility of the herb as a haemostatic in uterine haemorrhage and bleeding from nose. The herb is also used in sciatica, rheumatism and palsy. The treatment for paralysis comprises slapping the patient with a bundle of twigs. Alcoholic extract of Russian sp. is used in the cholecystitis and habitual constipation.

The root exhibits an antiprolifera- tive effect on prostatic epithelial and stromal cells. It may also lessen the effects of androgenic hormones by competitively blocking acess to human sex hormone binding globulin. (Planta Med, 63, 1997; ibid, 66, 2000. Also, ESCOP monograph; Altern Complem Ther, 1998; Simon Mills; Natural Medicines Comprehensive Database, 2007.)

In Europe, the juice of the leaves or roots, mixed with honey or sugar, was prescribed forbronchial asthma. In the USA, a freeze-dried preparation of the herb (300 mg gelatin capsules) has been found to improve condition of allergic rhinitis patients. The powdered seeds were considered a cure for goitre. (M. Grieve.)

The urticating properties of the hairs are attributed to the presence of acetyl- choline, histamine and 5-hydroxytryp- tamine (5-HT). A histamine-liberating enzyme is also present.

Acetylcholine is present in the leaves, rootlets, rhizomes and cortex in the ascending order of concentration. Histamine is not present in the underground parts of the plant. Its concentration in the leaves is about four times than that in the stem-cortex. Betaine and choline are present in the leaves.

The leaves gave flavonoids (including rutin), sterols, carotenoids, vitamins (including C, B group, K), minerals, plant phenolic acids. The coumarin scopoletin has been isolated from the flowers and the root.

A polysaccharide fraction obtained from aqueous extract showed anti- inflammatory activity in carrageenan- induced rat paw oedema and lymphocyte transformation test. A lectin was found to stimulate proliferation of human lymphocytes. (Planta Med, 55, 1989.)

The leaf and root is contraindicat- ed in kidney disease and pregnancy. 5-hydroxytryptamine is a uterotropic constituent. (Francis Brinker.)... urtica dioica

Antioxidants

Compounds that protect the body against free radical activity and lipid peroxidation. Free-radical scavengers. Low levels in the tissues reduce the span of human life. High levels enable humans to live longer. The greater the oxidation damage to the DNA, the shorter the lifespan.

Vitamins A, C and E inhibit production of free radicals. Especially effective is beta-carotene, the precursor of Vitamin A, found in carrots, spinach, yams and some green leafy vegetables. Vitamin E and Selenium work together to prevent free radical damage to cell membrane. Antioxidants act favourably on glaucoma, Parkinson’s disease and rheumatoid arthritis.

This group claims to have an anti-tumour effect. Epithelial cancers may invade the respiratory and gastro-intestinal tracts, lungs, skin and cervix of the womb. The higher the level of antioxidants in the cells, the lesser the risk of epithelial cell cancer, and blindness in the aged. vChief antioxidants: Alfalfa, Comfrey, Asparagus (fresh), Beet tops, Dandelion leaves, Ginseng, Gotu Kola, Goldenseal, Irish Moss, Parsley, Walnuts, Watercress, Wheat sprouts. Perhaps the cheapest and most effective is Garlic.

Diet. Highly coloured fruits and vegetables: oranges, red and green peppers, carrots, apricots, mangoes, liver and spinach.

Supplements. Beta carotene (Vitamin A), Vitamin C, Vitamin E, Selenium, Zinc. See: SOD, FREE RADICALS. ... antioxidants

Cilium

n. (pl. cilia) 1. a hairlike process, large numbers of which are found on certain epithelial cells and on certain (ciliate) protozoa. Cilia are particularly characteristic of the epithelium that lines the upper respiratory tract, where their beating serves to remove particles of dust and other foreign material. 2. an eyelash or eyelid. —ciliary adj.... cilium

Cytokeratin

n. a member of a family of proteins – *keratins – found in the cytoplasm of epithelial tissues and the cancers arising in them (*carcinomas). Any given carcinoma has its unique pattern of cytokeratins, which can be identified on histochemical analysis of a specimen and can help in the diagnosis of metastatic carcinoma when the primary site of metastasis is unknown.... cytokeratin

Dyskaryosis

n. the abnormal condition of a cell that has a nucleus showing the features characteristic of the earliest stage of malignancy, while retaining relatively normal cytoplasm. It may be seen, for example, in the squamous and columnar epithelial cells of a cervical smear (see cervical screening).... dyskaryosis

Elschnig Pearls

round or oval transparent cystic structures on the posterior capsule of the lens due to proliferation of lens epithelial cells following extracapsular *cataract extraction. They can grow to cover the central part of the capsule and cause reduction in vision. [A. Elschnig (1863–1939), German ophthalmologist]... elschnig pearls

Beans, Broad

(Vivia faba), leguminosae.

Contain natural L-dopa which penetrates the intestinal epithelial cells and is transported through the blood stream to the brain capillaries where it is converted into dopamine, of value in the nutrition of Parkinson patients.

Beans should be eaten, not when fully mature, but when young, with a thin skin and easy to digest. Ninety per cent afflicted with Parkinson’s disease at an early age respond quickly. It is easily oxidised two or three days after harvest and vanishes completely as the plant stops growing and begins to dry. Patients report a marked improvement each time they eat a meal of fresh broad beans and may not require drug treatment “for many hours”. The young beans are immersed in boiling water for three minutes, and may be eaten as a preventative. ... beans, broad

Cancer – Bladder

Neoplasm of bladder. One third of patients are over 70 years. Most cases today arise from exposure to injurious chemicals only partly eliminated from the body, as from food additives, analine dyes, etc. Evidence also links the disease to excessive coffee-drinking, the general consensus being that caffeine blocks the action of a compound named adenosine – one of the building blocks of DNA – involved in cellular energy. In this way it interferes with natural metabolic processes.

Symptoms: Blood in the urine with absence of pain on passing water in early stages. Then, burning frequency, especially at night. Kidneys become involved. Growths range from papilloma to tumour which may ulcerate in later stages.

The lesion is confirmed by cystoscopy (examination of the bladder by insertion of an instrument to illuminate inner surfaces and makes possible a direct view of the affected tissues). Even when the condition is healed this examination is repeatedly necessary to detect recurrence.

Two kinds: (1) papillary epithelioma (2) squamous cell epithelioma.

Tea. Formula. Equal parts: Marshmallow root, Clivers, Horsetail, Shepherd’s purse. 1-2 teaspoons to each cup boiling water; infuse 10-15 minutes. 2 cups or more daily.

Decoction. Barberry bark cold infusion. 1 teaspoon to each cup cold water. Steep over night. 2 cups or more daily.

Tinctures. Formula. Horsetail 1; Clivers 2; Barberry 1. Mix. 1-2 teaspoons (5-10ml) 2 or more times daily. If inflammation is present add Meadowsweet 1.

Dr William Boericke, physician, advised Dandelion to lessen symptoms.

Diet. See: DIET – CANCER.

Supplements. Emphasis on Vitamins A and C. (Vitamin A in epithelial tumours, ‘New Scientist’ (1975) 303)

Treatment offered as a supportive to specific modern hospital techniques. Treatment by or in liaison with a general medical practitioner. ... cancer – bladder

Cancer – Tongue

May be scirrhus or epithelial.

Causes. Smoking, alcohol, jagged teeth, chemical irritants, septic toxins, sprayed fruit and vegetables, poisoning by lead, arsenic and other chemicals, additives, hot foods, spicy curries and peppers, chewing tobacco.

Over 80 per cent found to be present in old syphilitic cases. Charles Ryall, surgeon, Cancer Hospital, regarded the two as comparable with that between syphilis and tabes. Dr F. Foester, Surgeon, concluded that epithelioma of the tongue as far more frequently preceded by syphilis than any other form of cancer.

(Hastings Gilford FRCS, “Tumours and Cancers”)

The condition may arise from a gumma or patch of leucoplakia (white patches) – at one time known as smoker’s tongue.

Of possible value. Alternatives:– Many plants have been shown to produce neoplastic activity, as observed in discovery of anti-cancer alkaloids of the Vinca plant (Vinchristine) and Mistletoe. Dr Wm Boericke confirms clinical efficacy of Clivers, promoting healthy granulations in ulcers and tumour of the tongue. Dr W.H. Cook advises a mouthwash of Goldenseal. For scirrhous hardening, juice of fresh Houseleek has a traditional reputation.

Tinctures. Equal parts Condurango and Goldenseal. 30-60 drops before meals in water; drops increased according to tolerance.

Local paint. Thuja lotion.

Case record. Dr Brandini, Florence, had a patient, 71, with inoperable cancer of the tongue. In the midst of his pain he asked for a lemon which immediately assuaged the pain. The next day gave him even greater relief. The doctor tried it on a number of similar patients with the same results, soaking lint in lemon juice.

Diet. See: DIET – CANCER.

Treatment by a general medical practitioner or hospital oncologist. ... cancer – tongue

Endophytic

adj. describing growth inwards from an epithelial surface due to invasion of the surrounding tissues. Endophytic growth is characteristic of carcinomas. Compare exophytic.... endophytic

Epithalaxia

n. loss of layers of epithelial cells from the lining of the intestine.... epithalaxia

Exocrine Gland

a gland that discharges its secretion by means of a duct, which opens onto an epithelial surface. An exocrine gland may be simple, with a single unbranched duct, or compound, with branched ducts and multiple secretory sacs. The illustration shows some different types of these glands. Examples of exocrine glands are the sebaceous and sweat glands. See also secretion.... exocrine gland

Exophytic

adj. describing growth outwards from an epithelial surface. Exophytic growth is characteristic of benign epithelial tumours but carcinomas may also have an exophytic growth component. Compare endophytic.... exophytic

Germinal Epithelium

the epithelial covering of the ovary, which was formerly thought to be the site of formation of *oogonia. It is now thought that the oogonia persist in a dormant state from the prenatal period until required in reproductive life.... germinal epithelium

Hyalin

n. a clear glassy material produced as the result of degeneration in certain tissues, particularly connective tissue and epithelial cells.... hyalin

Keratin

n. one of a family of proteins that are the major constituents of the nails, hair, and the outermost layers of the skin. The cytoplasm of epithelial cells, including *keratinocytes, contains a network of keratin filaments.... keratin

Cancer – Oesophagus

Usually epithelial in character, similar to that of the lips. Mostly in males.

Seldom before 45 years. Frequently in lower one-third of gullet. Dysphagia, with sense of obstruction on swallowing food. May perforate wall of trachea. Pain, worse at night, radiates from an exact spot. Eating hot food and drinking piping hot tea are heavily suspect.

At risk. Heavy smokers and alcoholics with depleted reserves of Vitamin A and zinc. These two factors play an important role in modern treatment.

Occurs in areas where the soil is low in molybdenum which causes plants to have a high level of nitrates. When such plants are stored they form nitrites which in turn form nitrosamines – which are carcinogens. Experimental rats given nitrous amines have a strong tendency to form cancer of the oesophagus. Eating pickled vegetables carries a high risk.

There are a few areas of the world where these adverse soil conditions pertain – one in Iran, another in Calvados, but the worst was in Lin Xian of the province of Honan, China. In Lin Xian, in the 1970s, it was found that villagers ate mainly persimmon and corn cakes and pickled vegetables. These, and their water, were high in nitrates. It was also their habit to eat mouldy bread which is high in amines – even nitrosamines. Their food was deficient in Vitamin C, which is likely to produce nitrous amines in the stomach.

The molybdenum problem was solved by sowing seeds with a fertiliser containing molybdenum. Piped water replaced old cistern wells and food was carefully stored. Even the chickens oesophageal cancers were cured. As a result of modern scientific investigation and treatment in which medicinal herbs made an important contribution, what was once a high gullet cancer area was resolved into one of the success stories of modern medicine.

Tannin has long been identified as a cancer-causing chemical, supported by findings of a high incidence of the disease among those who consume large quantities of tannin-containing beverages such as tea. Milk binds with tannin and is advised in tea-drinking where lemon is not taken.

Solid drugs and tablets should not be swallowed in the recumbent position without chewing a piece of banana.

Symptoms. (1) Sensation of obstruction when swallowing food. (2) Sharp pain behind breastbone. (3) “Something stuck in the gullet.” (4) Stomach ache, dry throat. (5) Belching when taking food. (6) Soreness of the upper back. (Dr Ge-ming, Lin Xian, Province of Honan, Chinese People’s Republic)

Of possible value. Alternatives:– Tea. Equal parts: Chaparral, Gotu Kola, Red Clover. 1 heaped teaspoon to each cup boiling water; infuse 15 minutes. Drink freely.

Powders. Combination. Goldenseal 1; Echinacea 2; Slippery Elm 3. Dose: 750mg (three 00 capsules or half a teaspoon). 3 or more times daily.

Tinctures. Combination. Goldenseal 1; Bayberry 1; Thuja 1; Condurango 1; Rosebay Willowherb 2. One teaspoon 3 or more times daily.

Chinese Herbalism. Powdered Huang yao-tzu 3 ch’ien, 3 times daily. Remedy is prepared by taking 12 liang of huang yao-tzu and steeping in 3 chin of white wine 24 hours. Then place huang yao-tzu in cold water and soak for another 7 days and 7 nights. Take out, dry and crush into powder. (A Barefoot Doctor’s Manual)

Diet. Leafy vegetables, carrots, tomatoes and fruit help to protect against the disease. Supplements. Especially Vitamin A, zinc and molybdenum.

Treatment by a general medical practitioner or hospital oncologist. ... cancer – oesophagus

Condurango

Marsdenia cundurango, Rchb. Condor plant sought by the condor eagle in the mountains of Ecuador and Peru. Dried bark.

Constituents: glycosides, essential oils.

Action: alterative, circulatory stimulant, stomach relaxant, bitter, adaptogenic, orexigenic.

Uses: Nervous indigestion, anorexia nervosa, neoplasm of stomach and intestines. Calms pain in stomach disorders following gastric ulcer and lessens vomiting (Le Monde Medical Journal). Condurango has found its chief use as a cancer remedy, especially those originating in epithelial structures, epitheliolma, etc. (John Clarke MD)

Preparations: Thrice daily.

Powder: 1-4g in honey, or milk.

Liquid Extract. Dose: 2-4ml. (30-60 drops) in water. Tea: 1-4g to cup boiling water. Half-1 cup. ... condurango

Ear Drums, Perforated

Sliced Garlic treatment. Peel corm, leaving transparent epithelial-layer attached. Cut slice and shape it to cover the perforation; push it against the eardrum so that its cut surface hugs the perforation. Pack the external auditory meatus with an alcohol-moistened plug of cotton wool. Water must not enter the ear and forceful nose-blowing avoided. Replace Garlic slice once or twice a week until healing is complete. If middle ear becomes inflamed with excessive exudate, stop treatment and give an anti-inflammatory (such as Echinacea, author). Any exudation usually stops when treatment is discontinued. (Chinese Medical Journal, May 1977) ... ear drums, perforated

Keratitis

n. inflammation of the *cornea of the eye. It may be due to physical or chemical agents (abrasions, exposure to dust, chemicals, ultraviolet light, etc.) or result from infection. The eye waters and is very painful, and vision is blurred. In disciform keratitis a disc-shaped patch of oedema and inflammation develops in the cornea, usually as an immune response to viral infection, commonly herpes simplex. Filamentary keratitis is associated with small mucoid deposits of epithelial filaments on the surface of the cornea, which come off to leave small corneal erosions that cause severe pain until they heal.... keratitis

Lasek

laser in situ epithelial keratomileusis: a technique of laser refractive eye surgery used to correct both short sight (myopia) and long sight (hypermetropia). A flap of corneal epithelium is raised, the surface of the cornea is reshaped using an *excimer laser, and the epithelium is then replaced.... lasek

Microvillus

n. (pl. microvilli) one of a number of microscopic hairlike structures (about 5 ?m long) projecting from the surface of epithelial cells (see epithelium). They serve to increase the surface area of the cell and are seen on absorptive and secretory cells. In some regions (particularly the intestinal tract) microvilli form a dense covering on the free surface of the cells: this is called a brush border.... microvillus

Mouthwash Test

a simple noninvasive procedure that enables the detection of *carriers for single gene defects, e.g. *cystic fibrosis. Epithelial cells from the buccal cavity are obtained from a saline mouthwash: from these it is possible to isolate DNA, which is amplified by the *polymerase chain reaction to enable gene analysis.... mouthwash test

Eyes – Infection

Whatever the infection, dendritic ulcer, corneal ulcer, herpes simplex or stye, treatment should be internal as well as external.

A study carried out at Moorfields Eye Hospital, London, has shown that those who use extended-wear soft contact lenses are more likely to develop microbial keratitis than users of other lenses.

Treatment. Internal: Powders, Tinctures or Liquid Extracts. Combine Echinacea 2; Blue Flag 1; Goldenseal 1. Doses: Powders: 500mg (one-third teaspoon or two 00 capsules). Liquid Extracts 30-60 drops.

Tinctures: 1-2 teaspoons. In water, or honey.

Comfrey. To promote epithelial regeneration. Potential benefit far outweighs possible risk.

Evening Primrose capsules.

Topical. Alternatives. (1) Goldenseal Eye Lotion: 1 part Goldenseal root macerated in 40 parts distilled extract of Witch Hazel 2-3 days. Strain. 5-10 drops in eyebath half filled with warm water; douche. Wipe eyelids. (2) Aloe Vera juice or gel. (3) Moisten Chamomile teabag with warm water and fix over eye for styes, etc. (4) Bathe with Periwinkle minor tea: 2 teaspoons to cup boiling water allowed to cool and strain. (5) Elderflower water. The above to relieve pain, redness and gritty sensation. (6) Evening Primrose lotion. (7) Raw carrot compress to ripen stye. Nasturtium seed compress.

Supplements. Daily. Vitamin A 7500iu, Vitamin B2 10mg, Vitamin C 3g, Vitamin E 400iu, Zinc 15mg. Referral to consultant ophthalmologist. ... eyes – infection

Eye Injuries

From blows, burns, chemicals or haemorrhage. Hospital treatment may be required. Petechial haemorrhage (Witch Hazel douche). For infection, add Echinacea. For shock, German Chamomile tea.

Topical. Alternatives. Flashburns from welding etc – fresh juice Aloe Vera gave instant relief and speeded recovery. (New England Journal of Medicine, Vol 311, 6, p.413) Houseleek juice. Wounds that refuse to heal: cotton wool pad saturated with Castor oil overnight. Chamomile compress. Bathe with teas of Plantain, Horsetail, Chickweed, Blessed Thistle, Self-Heal, Comfrey especially commended to encourage epithelial healing.

Diet. Bilberries, rich in flavonoids which are anti-inflammatory and healing. As desired.

Supplements. Daily. Vitamin A 7500iu, Vitamin B-complex, Vitamin C 3g, Vitamin E 1000iu, Beta- carotene. Selenium 300mcg, Zinc 15mg.

Referral to a consultant ophthalmologist. ... eye injuries

Cervical Cancer

(cervical carcinoma) cancer of the neck (cervix) of the uterus. The tumour may develop from the surface epithelium of the cervix (squamous carcinoma) or from the epithelial lining of the cervical canal (adenocarcinoma). In both cases the tumour is invasive, spreading to involve surrounding tissue and subsequently to neighbouring lymph nodes and adjacent organs, such as the bladder and rectum. Cancer of the cervix can be detected in an early stage of development (see cervical screening) and diagnosis is established by biopsy (see colposcopy). In carcinoma in situ (see cervical intraepithelial neoplasia) the tumour is confined to the epithelium: there is no invasion of surrounding tissue but, if untreated (by local ablation, *LLETZ, or surgical excision), it can become invasive. Common early features of invasive disease are abnormal vaginal bleeding and a foul-smelling blood-stained vaginal discharge. Treatment is by surgery with or without postoperative radiotherapy. See also human papillomavirus.... cervical cancer

Intention

n. 1. a process of healing. Healing by first intention is the natural healing of a wound or surgical incision when the edges are brought together under aseptic conditions and *granulation tissue forms. In healing by second intention the wound edges are separated and the cavity is filled with granulation tissue over which epithelial tissue grows from the wound edges. In healing by third intention the wound ulcerates, granulations are slow to form, and a scar forms at the wound site. 2. evaluation of a person’s aims or purpose in undergoing an action, which is important for the assessment and attribution of responsibility in ethicolegal questions and defined legally for the purposes of criminal law. See also doctrine of double effect.... intention

Myoepithelium

n. a tissue consisting of cells of epithelial origin having a contractile cytoplasm. Myoepithelial cells play an important role in encouraging the secretion of substances into ducts.... myoepithelium

Nephrin

n. a transmembrane protein localized to the slit diaphragm of the *podocyte and necessary for the proper functioning of the renal filtration barrier. The latter consists of fenestrated endothelial cells, the basement membrane, and the epithelial podocyte. A defect in the gene coding for nephrin (NPHS1) on chromosome 19 results in congenital nephrotic syndrome of Finnish type (which is not exclusive to the Finnish population).... nephrin

Oncocytoma

n. a usually benign tumour that consists of oncocytes, which are abnormal epithelial cells that contain many mitochondria. Oncocytomas commonly occur in the kidney.... oncocytoma

Papillary

adj. nipple-like. Papillary epithelial neoplasms are composed of slender fronds of epithelial cells supported by fine fibrovascular cores. See papilloma.... papillary

Pedunculated

adj. having a stalk or stemlike attachment to an epithelial surface. Pedunculated tumours are commonly, but not invariably, benign.... pedunculated

Photodynamic Diagnosis

a technique for improving the sensitivity and specificity of bladder cancer diagnosis at cystoscopy using a light-sensitive agent. This agent is instilled into the bladder, taken up by the epithelial cells, and converted into a porphyrin that accumulates only in malignant and premalignant cells. It fluoresces under light of a specific wavelength and is thus highlighted against normal bladder mucosa.... photodynamic diagnosis

Paget’s Disease

1. a chronic disease of bones, occurring in the elderly and most frequently affecting the skull, backbone, pelvis, and long bones. Affected bones become thickened and their structure disorganized: X-rays reveal patchy *sclerosis. There are often no symptoms, but pain, deformity, and fracture can occur; when the skull is affected, blindness and deafness can occur due to nerve compression. There is a very small (1%) risk of malignant change (*osteosarcoma). Treatment is with *bisphosphonates. Medical name: osteitis deformans. 2. a malignant condition of the nipple, resembling eczema in appearance, associated with underlying infiltrating cancer of the breast. See also breast cancer. 3. an uncommon condition of the vulva characterized by an epithelial lesion that histologically resembles the lesion of Paget’s disease of the nipple. It may be associated with locally invasive *adenocarcinomas of the surrounding skin, as well as tumours at other sites. [Sir J. Paget (1814–99), British surgeon]... paget’s disease

Podocyte

n. an epithelial cell in the *glomerulus that spreads over the capillary basement membrane and has branching tentacle-like processes that interdigitate with adjacent cells. The podocytes leave gaps or thin filtration slits. The slits are covered by slit diaphragms, which are composed of a number of cell-surface proteins including *nephrin, podocalyxin, and P-cadherin, which ensure that large molecules, such as albumin and gammaglobulin, are not filtered. Podocytes are damaged in *minimal change nephropathy and a major target of injury in *HIVAN.... podocyte

Preneoplastic

adj. preceding the formation of a benign or malignant tumour (neoplasm). Preneoplastic lesions have the potential to give rise to tumours at that site. For example, mammary ductal epithelial *hyperplasia can give rise to *ductal carcinoma in situ. Preneoplastic conditions may result in tumours at that site or elsewhere. For example, ulcerative colitis predisposes to the development of colorectal *adenocarcinoma and *cholangiocarcinoma.... preneoplastic

Pseudocyst

n. a fluid-filled space within an organ that is not enclosed by an epithelial lining. A pancreatic pseudocyst may develop in cases of chronic pancreatitis or as a complication of acute pancreatitis. As the pseudocyst expands it may cause abdominal pain accompanied by a rise in the level of pancreatic enzymes in the blood. It may be felt by abdominal examination or identified by radiological imaging. Treatment is by endoscopic or radiological drainage or by surgery (see marsupialization).... pseudocyst

Tonofibril

n. a tiny fibre occurring in bundles in the cytoplasm of cells that lie in contact, as in epithelial tissue. Tonofibrils are concerned with maintaining contact between adjacent cells. See desmosome.... tonofibril

Trantas Dots

slightly elevated greyish-white dots consisting of clumps of degenerating eosinophils and epithelial cells, seen on the conjunctiva at the junction of the cornea and sclera in cases of allergic conjunctivitis. [A. Trantas (1867–1960), Greek ophthalmologist]... trantas dots

Ulcer

n. 1. a break in an epithelial surface. See also dendritic ulcer. 2. a break in the skin extending to all its layers, or a break in the mucous membrane lining the alimentary tract, that fails to heal and is often accompanied by inflammation. Of the many types of skin ulcer, the most common is the venous (or hypostatic) ulcer of the leg, known incorrectly as a varicose ulcer, which is caused by increased venous pressure and usually occurs in older women. See also arterial ulcer; pressure sore.

For ulcers of the alimentary tract, see aphthous ulcer; duodenal ulcer; gastric ulcer; peptic ulcer; stress ulcers.... ulcer

Warthin’s Tumour

(adenolymphoma) a tumour of the parotid salivary glands, containing epithelial and lymphoid tissues with cystic spaces. [A. S. Warthin (1866–1931), US pathologist]... warthin’s tumour



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