Keratitis Health Dictionary

Keratitis: From 4 Different Sources


Inflammation of the cornea. It often takes the form of a corneal ulcer and may result from injury, contact with chemicals, or an infection. Symptoms of keratitis include pain and excessive watering of the eye, blurring of vision, and photophobia. Noninfective keratitis is treated by covering the affected eye. Drugs such as antibiotics may be given to treat infective keratitis.
Health Source: BMA Medical Dictionary
Author: The British Medical Association
See under EYE, DISORDERS OF.
Health Source: Medical Dictionary
Author: Health Dictionary
n. inflammation of the *cornea of the eye. It may be due to physical or chemical agents (abrasions, exposure to dust, chemicals, ultraviolet light, etc.) or result from infection. The eye waters and is very painful, and vision is blurred. In disciform keratitis a disc-shaped patch of oedema and inflammation develops in the cornea, usually as an immune response to viral infection, commonly herpes simplex. Filamentary keratitis is associated with small mucoid deposits of epithelial filaments on the surface of the cornea, which come off to leave small corneal erosions that cause severe pain until they heal.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Eye Injuries

Victims of eye injuries are advised to seek prompt medical advice if the injury is at all serious or does not resolve with simple ?rst-aid measures – for example, by washing out a foreign body using an eye bath.

Blunt injuries These may cause haemorrhage inside the eye, cataract, retinal detachment or even rupture of the eye (see also EYE, DISORDERS OF). Injuries from large blunt objects – for example, a squash ball – may also cause a ‘blow-out fracture’ of the orbital ?oor resulting in double vision. Surgical treatment may be required depending on the patient’s speci?c problems.

Chemical burns Most chemical splashes cause conjunctivitis and super?cial keratitis in the victim (see EYE, DISORDERS OF); both conditions are self-limiting. Alkalis are, however, more likely to penetrate deeper into the eye and cause permanent damage, particularly to the cornea. Prompt irrigation is important. Further treatment may involve testing the pH of the tears, topical antibiotics and CORTICOSTEROIDS, and vitamin C (drops or tablets – see APPENDIX 5: VITAMINS), depending on the nature of the injury.

Corneal abrasion Loss of corneal epithelium (outermost layer). Almost any sort of injury to the eye may cause this. The affected eye is usually very painful. In the absence of other problems, the epithelium heals rapidly: small defects may close within 24 hours. Treatment conventionally consists of antibiotic ointment and sometimes a pad over the injured eye.

Foreign bodies Most foreign bodies which hit the eye are small and are found in the conjunctival sac or on the cornea; most are super?cial and can be easily removed. A few foreign bodies penetrate deeper and may cause infection, cataract, retinal detachment or haemorrhage within the eye. The foreign body is usually removed and the damage repaired; nevertheless the victim’s sight may have been permanently damaged. Particularly dangerous activities include hammering or chiselling on metal or stone; people carrying out these activities (and others, such as hedge-cutting and grass-strimming) should wear protective goggles.... eye injuries

Eye, Disorders Of

Arcus senilis The white ring or crescent which tends to form at the edge of the cornea with age. It is uncommon in the young, when it may be associated with high levels of blood lipids (see LIPID).

Astigmatism (See ASTIGMATISM.)

Blepharitis A chronic in?ammation of the lid margins. SEBORRHOEA and staphylococcal infection are likely contributors. The eyes are typically intermittently red, sore and gritty over months or years. Treatment is di?cult and may fail. Measures to reduce debris on the lid margins, intermittent courses of topical antibiotics, steroids or systemic antibiotics may help the sufferer.

Blepharospasm Involuntary closure of the eye. This may accompany irritation but may also occur without an apparent cause. It may be severe enough to interfere with vision. Treatment involves removing the source of irritation, if present. Severe and persistent cases may respond to injection of Botulinum toxin into the orbicularis muscle.

Cataract A term used to describe any opacity in the lens of the eye, from the smallest spot to total opaqueness. The prevalence of cataracts is age-related: 65 per cent of individuals in their sixth decade have some degree of lens opacity, while all those over 80 are affected. Cataracts are the most important cause of blindness worldwide. Symptoms will depend on whether one or both eyes are affected, as well as the position and density of the cataract(s). If only one eye is developing a cataract, it may be some time before the person notices it, though reading may be affected. Some people with cataracts become shortsighted, which in older people may paradoxically ‘improve’ their ability to read. Bright light may worsen vision in those with cataracts.

The extent of visual impairment depends on the nature of the cataracts, and the ?rst symptoms noticed by patients include di?culty in recognising faces and in reading, while problems watching television or driving, especially at night, are pointers to the condition. Cataracts are common but are not the only cause of deteriorating vision. Patients with cataracts should be able to point to the position of a light and their pupillary reactions should be normal. If a bright light is shone on the eye, the lens may appear brown or, in advanced cataracts, white (see diagram).

While increasing age is the commonest cause of cataract in the UK, patients with DIABETES MELLITUS, UVEITIS and a history of injury to the eye can also develop the disorder. Prolonged STEROID treatment can result in cataracts. Children may develop cataracts, and in them the condition is much more serious as vision may be irreversibly impaired because development of the brain’s ability to interpret visual signals is hindered. This may happen even if the cataracts are removed, so early referral for treatment is essential. One of the physical signs which doctors look for when they suspect cataract in adults as well as in children is the ‘red re?ex’. This is observable when an ophthalmoscopic examination of the eye is made (see OPHTHALMOSCOPE). Identi?cation of this red re?ex (a re?ection of light from the red surface of the retina –see EYE) is a key diagnostic sign in children, especially young ones.

There is no e?ective medical treatment for established cataracts. Surgery is necessary and the decision when to operate depends mainly on how the cataract(s) affect(s) the patient’s vision. Nowadays, surgery can be done at any time with limited risk. Most patients with a vision of 6/18 – 6/10 is the minimum standard for driving – or worse in both eyes should

E

bene?t from surgery, though elderly people may tolerate visual acuity of 6/18 or worse, so surgery must be tailored to the individual’s needs. Younger people with a cataract will have more demanding visual requirements and so may opt for an ‘earlier’ operation. Most cataract surgery in Britain is now done under local anaesthetic and uses the ‘phaco-emulsi?cation’ method. A small hole is made in the anterior capsule of the lens after which the hard lens nucleus is liqui?ed ultrasonically. A replacement lens is inserted into the empty lens bag (see diagram). Patients usually return to their normal activities within a few days of the operation. A recent development under test in the USA for children requiring cataract operations is an intra-ocular ?exible implant whose magnifying power can be altered as a child develops, thus precluding the need for a series of corrective operations as happens now.

Chalazion A ?rm lump in the eyelid relating to a blocked meibomian gland, felt deep within the lid. Treatment is not always necessary; a proportion spontaneously resolve. There can be associated infection when the lid becomes red and painful requiring antibiotic treatment. If troublesome, the chalazion can be incised under local anaesthetic.

Conjunctivitis In?ammation of the conjunctiva (see EYE) which may affect one or both eyes. Typically the eye is red, itchy, sticky and gritty but is not usually painful. Redness is not always present. Conjunctivitis can occasionally be painful, particularly if there is an associated keratitis (see below) – for example, adenovirus infection, herpetic infection.

The cause can be infective (bacteria, viruses or CHLAMYDIA), chemical (e.g. acids, alkalis) or allergic (e.g. in hay fever). Conjunctivitis may also be caused by contact lenses, and preservatives or even the drugs in eye drops may cause conjunctival in?ammation. Conjunctivitis may addtionally occur in association with other illnesses – for example, upper-respiratory-tract infection, Stevens-Johnson syndrome (see ERYTHEMA – erythema multiforme) or REITER’S SYNDROME. The treatment depends on the cause. In many patients acute conjunctivitis is self-limiting.

Dacryocystitis In?ammation of the lacrimal sac. This may present acutely as a red, painful swelling between the nose and the lower lid. An abscess may form which points through the skin and which may need to be drained by incision. Systemic antibiotics may be necessary. Chronic dacryocystitis may occur with recurrent discharge from the openings of the tear ducts and recurrent swelling of the lacrimal sac. Obstruction of the tear duct is accompanied by watering of the eye. If the symptoms are troublesome, the patient’s tear passageways need to be surgically reconstructed.

Ectropion The lid margin is everted – usually the lower lid. Ectropion is most commonly associated with ageing, when the tissues of the lid become lax. It can also be caused by shortening of the skin of the lids such as happens with scarring or mechanical factors – for example, a tumour pulling the skin of the lower lid downwards. Ectropion tends to cause watering and an unsightly appearance. The treatment is surgical.

Entropion The lid margin is inverted – usually the lower lid. Entropion is most commonly associated with ageing, when the tissues of the lid become lax. It can also be caused by shortening of the inner surfaces of the lids due to scarring – for example, TRACHOMA or chemical burns. The inwardly directed lashes cause irritation and can abrade the cornea. The treatment is surgical.

Episcleritis In?ammation of the EPISCLERA. There is usually no apparent cause. The in?ammation may be di?use or localised and may affect one or both eyes. It sometimes recurs. The affected area is usually red and moderately painful. Episcleritis is generally not thought to be as painful as scleritis and does not lead to the same complications. Treatment is generally directed at improving the patient’s symptoms. The in?ammation may respond to NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) or topical CORTICOSTEROIDS.

Errors of refraction (Ametropia.) These will occur when the focusing power of the lens and cornea does not match the length of the eye, so that rays of light parallel to the visual axis are not focused at the fovea centralis (see EYE). There are three types of refractive error: HYPERMETROPIA or long-sightedness. The refractive power of the eye is too weak, or the eye is too short so that rays of light are brought to a focus at a point behind the retina. Longsighted people can see well in the distance but generally require glasses with convex lenses for reading. Uncorrected long sight can lead to headaches and intermittent blurring of vision following prolonged close work (i.e. eye strain). As a result of ageing, the eye becomes gradually long-sighted, resulting in many people needing reading glasses in later life: this normal process is known as presbyopia. A particular form of long-sightedness occurs after cataract extraction (see above). MYOPIA(Short sight or near sight.) Rays of light are brought to a focus in front of the retina because the refractive power of the eye is too great or the eye is too short. Short-sighted people can see close to but need spectacles with concave lenses in order to see in the distance. ASTIGMATISMThe refractive power of the eye is not the same in each meridian. Some rays of light may be focused in front of the retina while others are focused on or behind the retina. Astigmatism can accompany hypermetropia or myopia. It may be corrected by cylindrical lenses: these consist of a slice from the side of a cylinder (i.e. curved in one meridian and ?at in the meridian at right-angles to it).

Keratitis In?ammation of the cornea in response to a variety of insults – viral, bacterial, chemical, radiation, or mechanical trauma. Keratitis may be super?cial or involve the deeper layers, the latter being generally more serious. The eye is usually red, painful and photophobic. Treatment is directed at the cause.

Nystagmus Involuntary rhythmic oscillation of one or both eyes. There are several causes including nervous disorders, vestibular disorders, eye disorders and certain drugs including alcohol.

Ophthalmia In?ammation of the eye, especially the conjunctiva (see conjunctivitis, above). Ophthalmia neonatorum is a type of conjunctivitis that occurs in newborn babies. They catch the disease when passing through an infected birth canal during their mother’s labour (see PREGNANCY AND LABOUR). CHLAMYDIA and GONORRHOEA are the two most common infections. Treatment is e?ective with antibiotics: untreated, the infection may cause permanent eye damage.

Pinguecula A benign degenerative change in the connective tissue at the nasal or temporal limbus (see EYE). This is visible as a small, ?attened, yellow-white lump adjacent to the cornea.

Pterygium Overgrowth of the conjunctival tissues at the limbus on to the cornea (see EYE). This usually occurs on the nasal side and is associated with exposure to sunlight. The pterygium is surgically removed for cosmetic reasons or if it is thought to be advancing towards the visual axis.

Ptosis Drooping of the upper lid. May occur because of a defect in the muscles which raise the lid (levator complex), sometimes the result of ageing or trauma. Other causes include HORNER’S SYNDROME, third cranial nerve PALSY, MYASTHENIA GRAVIS, and DYSTROPHIA MYOTONICA. The cause needs to be determined and treated if possible. The treatment for a severely drooping lid is surgical, but other measures can be used to prop up the lid with varying success.

Retina, disorders of The retina can be damaged by disease that affects the retina alone, or by diseases affecting the whole body.

Retinopathy is a term used to denote an abnormality of the retina without specifying a cause. Some retinal disorders are discussed below. DIABETIC RETINOPATHY Retinal disease occurring in patients with DIABETES MELLITUS. It is the commonest cause of blind registration in Great Britain of people between the ages of 20 and 65. Diabetic retinopathy can be divided into several types. The two main causes of blindness are those that follow: ?rst, development of new blood vessels from the retina, with resultant complications and, second, those following ‘water logging’ (oedema) of the macula. Treatment is by maintaining rigid control of blood-sugar levels combined with laser treatment for certain forms of the disease – in particular to get rid of new blood vessels. HYPERTENSIVE RETINOPATHY Retinal disease secondary to the development of high blood pressure. Treatment involves control of the blood pressure (see HYPERTENSION). SICKLE CELL RETINOPATHY People with sickle cell disease (see under ANAEYIA) can develop a number of retinal problems including new blood vessels from the retina. RETINOPATHY OF PREMATURITY (ROP) Previously called retrolental ?broplasia (RLF), this is a disorder affecting low-birth-weight premature babies exposed to oxygen. Essentially, new blood vessels develop which cause extensive traction on the retina with resultant retinal detachment and poor vision. RETINAL ARTERY OCCLUSION; RETINAL VEIN OCCLUSION These result in damage to those areas of retina supplied by the affected blood vessel: the blood vessels become blocked. If the peripheral retina is damaged the patient may be completely symptom-free, although areas of blindness may be detected on examination of ?eld of vision. If the macula is involved, visual loss may be sudden, profound and permanent. There is no e?ective treatment once visual loss has occurred. SENILE MACULAR DEGENERATION (‘Senile’ indicates age of onset and has no bearing on mental state.) This is the leading cause of blindness in the elderly in the western world. The average age of onset is 65 years. Patients initially notice a disturbance of their vision which gradually progresses over months or years. They lose the ability to recognise ?ne detail; for example, they cannot read ?ne print, sew, or recognise people’s faces. They always retain the ability to recognise large objects such as doors and chairs, and are therefore able to get around and about reasonably well. There is no e?ective treatment in the majority of cases. RETINITIS PIGMENTOSAA group of rare, inherited diseases characterised by the development of night blindness and tunnel vision. Symptoms start in childhood and are progressive. Many patients retain good visual acuity, although their peripheral vision is limited. One of the characteristic ?ndings on examination is collections of pigment in the retina which have a characteristic shape and are therefore known as ‘bone spicules’. There is no e?ective treatment. RETINAL DETACHMENTusually occurs due to the development of a hole in the retina. Holes can occur as a result of degeneration of the retina, traction on the retina by the vitreous, or injury. Fluid from the vitreous passes through the hole causing a split within the retina; the inner part of the retina becomes detached from the outer part, the latter remaining in contact with the choroid. Detached retina loses its ability to detect light, with consequent impairment of vision. Retinal detachments are more common in the short-sighted, in the elderly or following cataract extraction. Symptoms include spots before the eyes (?oaters), ?ashing lights and a shadow over the eye with progressive loss of vision. Treatment by laser is very e?ective if caught early, at the stage when a hole has developed in the retina but before the retina has become detached. The edges of the hole can be ‘spot welded’ to the underlying choroid. Once a detachment has occurred, laser therapy cannot be used; the retina has to be repositioned. This is usually done by indenting the wall of the eye from the outside to meet the retina, then making the retina stick to the wall of the eye by inducing in?ammation in the wall (by freezing it). The outcome of surgery depends largely on the extent of the detachment and its duration. Complicated forms of detachment can occur due to diabetic eye disease, injury or tumour. Each requires a specialised form of treatment.

Scleritis In?ammation of the sclera (see EYE). This can be localised or di?use, can affect the anterior or the posterior sclera, and can affect one or both eyes. The affected eye is usually red and painful. Scleritis can lead to thinning and even perforation of the sclera, sometimes with little sign of in?ammation. Posterior scleritis in particular may cause impaired vision and require emergency treatment. There is often no apparent cause, but there are some associated conditions – for example, RHEUMATOID ARTHRITIS, GOUT, and an autoimmune disease affecting the nasal passages and lungs called Wegener’s granulomatosis. Treatment depends on severity but may involve NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS), topical CORTICOSTEROIDS or systemic immunosuppressive drugs.

Stye Infection of a lash follicle. This presents as a painful small red lump at the lid margin. It often resolves spontaneously but may require antibiotic treatment if it persists or recurs.

Sub-conjunctival haemorrhage Haemorrhage between the conjunctiva and the underlying episclera. It is painless. There is usually no apparent cause and it resolves spontaneously.

Trichiasis Inward misdirection of the lashes. Trichiasis occurs due to in?ammation of or trauma to the lid margin. Treatment involves removal of the patient’s lashes. Regrowth may be prevented by electrolysis, by CRYOTHERAPY to the lid margin, or by surgery.

For the subject of arti?cial eyes, see under PROSTHESIS; also GLAUCOMA, SQUINT and UVEITIS.... eye, disorders of

Interstitial

Interstitial is a term applied to indi?erent tissue set among the proper active tissue of an organ. It is generally of a supporting character and formed of ?brous tissue. The term is also applied to the ?uid always present in this in a small amount, and to diseases which specially affect this tissue, such as interstitial keratitis.... interstitial

Selenium Sulphide

This is used as a shampoo in the treatment of dandru? and seborrhoeic DERMATITIS of the scalp. In view of its potential toxicity it should only be used under medical supervision. It must never be applied to in?amed areas of the scalp, and it must not be allowed to get into the eyes as it may cause conjunctivitis or keratitis. It is also used in the treatment of tinea versicolor (see RINGWORM).... selenium sulphide

Contact Lens Fatigue

Irritation, soreness, friction, inflammation. “People who use extended- wear soft contact lenses are more likely to develop serious microbial keratitis infection than users of other lenses.” (Research team, Moorfields Eye Hospital, London) Risk of keratitis was seen to increase when soft lenses were worn for more than six days.

Alternatives:– Douche. Simple teas: Fennel or German Chamomile; half a teaspoon dried herb or teabag to cup boiling water. Infuse 15 minutes. Half-fill eye-bath and use as douche, tepid. OR: quarter of a teaspoon distilled extract Witch Hazel in eye-bath; half-fill with water. Natural lubricant for contact lens is Evening Primrose oil (contents of a capsule). See: EYES, INFECTION.

Supplements. Daily. Vitamin A 7500iu, Vitamin B2 10mg, Vitamin C 400mg, Vitamin E 400iu, Beta carotene. Zinc 15mg. ... contact lens fatigue

Eyes – Foreign Body

From coal dust, insects, pollen, etc.

Symptoms: blinking, watering, acute discomfort. Sensation of grit in the eye does not always imply foreign body, but symptoms of conjunctivitis or keratitis. Automatic blinking is sometimes enough to clear offending object.

Treatment. External. Evert lid and remove. Swab out with dilute Witch Hazel on cotton wool. Inject one drop Castor oil, (also good for scratched cornea), Aloe Vera gel or juice. Fenugreek seed puree. Juice of Houseleek and dairy cream.

Difficult case. Removal of particles of iron or dust, apply mucilage of Slippery Elm powder to eye – patient lying on his back, a second person injecting it into corner of eye, the patient moving eye in opposite direction. Safe and healing. Clean eye and bathe with warm milk.

Referral to consultant ophthalmologist. ... eyes – foreign body

Eye, Painful Red

A common combination of eye symptoms that may be due to any of several eye disorders.

Uveitis is a common cause of dull, aching pain. The redness is caused by widening of blood vessels around the iris. Another serious cause of pain and redness in one eye is acute closedangle glaucoma. Other causes include keratitis, usually due to a corneal ulcer, or a foreign body in the eye (see eye, foreign body in). The most common cause of redness and irritation in the eye is conjunctivitis.... eye, painful red

Cogan’s Syndrome

a disorder in which *keratitis and iridocyclitis (see uveitis) are associated with tinnitus, vertigo, and bilateral sensorineural deafness. [D. G. Cogan (1908–93), US ophthalmologist]... cogan’s syndrome

Keratouveitis

n. inflammation involving both the cornea (see keratitis) and the uvea (see uveitis).... keratouveitis

Rosacea

n. a chronic inflammatory disease of the face in which the skin becomes abnormally flushed. At times it becomes pustular and there may be an associated *keratitis. The disease occurs in both sexes and at all ages but is most common in women in their thirties; the cause is unknown. Treatment is with topical metronidazole; oral tetracyclines, erythromycin, or isotretinoin; or pulsed dye laser.... rosacea

Eyes – Infection

Whatever the infection, dendritic ulcer, corneal ulcer, herpes simplex or stye, treatment should be internal as well as external.

A study carried out at Moorfields Eye Hospital, London, has shown that those who use extended-wear soft contact lenses are more likely to develop microbial keratitis than users of other lenses.

Treatment. Internal: Powders, Tinctures or Liquid Extracts. Combine Echinacea 2; Blue Flag 1; Goldenseal 1. Doses: Powders: 500mg (one-third teaspoon or two 00 capsules). Liquid Extracts 30-60 drops.

Tinctures: 1-2 teaspoons. In water, or honey.

Comfrey. To promote epithelial regeneration. Potential benefit far outweighs possible risk.

Evening Primrose capsules.

Topical. Alternatives. (1) Goldenseal Eye Lotion: 1 part Goldenseal root macerated in 40 parts distilled extract of Witch Hazel 2-3 days. Strain. 5-10 drops in eyebath half filled with warm water; douche. Wipe eyelids. (2) Aloe Vera juice or gel. (3) Moisten Chamomile teabag with warm water and fix over eye for styes, etc. (4) Bathe with Periwinkle minor tea: 2 teaspoons to cup boiling water allowed to cool and strain. (5) Elderflower water. The above to relieve pain, redness and gritty sensation. (6) Evening Primrose lotion. (7) Raw carrot compress to ripen stye. Nasturtium seed compress.

Supplements. Daily. Vitamin A 7500iu, Vitamin B2 10mg, Vitamin C 3g, Vitamin E 400iu, Zinc 15mg. Referral to consultant ophthalmologist. ... eyes – infection

Cornea

The transparent thin-walled dome that forms the front of the eyeball. The cornea is joined at its circumference to the sclera (white of the eye); the black pupil and the coloured iris are visible beneath it. The main functions of the cornea are to help focus light-rays on to the retina at the back of the eye and to protect the front of the eye. It is kept moist by tears produced by the lacrimal gland and the mucus- and fluid-secreting cells in the eyelids and conjunctiva. cornea, disorders of Injuries or diseases affecting the cornea, the outer shell of the eyeball. Injuries include corneal abrasions, which sometimes become infected and progress to a corneal ulcer. Penetrating corneal injuries can cause scarring, which may lead to impairment of vision. Chemical injuries can result from contact with a corrosive substance and require immediate flushing of the eye with water.

In actinic keratopathy, the outer layer of the cornea is damaged by ultraviolet light. In exposure keratopathy, damage is due to reduced protection by the tear film and blink reflex. The cornea can also be infected by viruses, bacteria, and fungi, the herpes simplex virus being especially dangerous. True inflammation of the cornea (called keratitis) is uncommon as the cornea contains no blood vessels.

Other disorders include: keratomalacia as a result of vitamin A deficiency; keratoconjunctivitis sicca (dry eye); corneal dystrophies such as keratoconus; and oedema, in which fluid builds up in the cornea and impairs vision.

Rare congenital defects include microcornea (smaller cornea than normal) or megalocornea (bigger than normal) and buphthalmos, or “ox-eye’’, in which the entire eyeball is distended as a result of glaucoma.

Degenerative conditions of the cornea such as calcium deposition, thinning, and spontaneous ulceration occur mainly in the elderly, and are more common in previously damaged eyes.... cornea

Syphilis

An infection caused by TREPONEMA PALLIDUM bacteria and spread through sexual intercourse or other intimate body contact, or, less commonly, from mother to fetus during pregnancy.

Following sexual infection, the organism spreads rapidly via the bloodstream and lymphatic system. The first symptom is a sore (chancre) that appears on the genitals, anus, rectum, lips, throat, or fingers and heals in 4–8 weeks. A rash then develops, which may be transient, recurrent, or may last for months. Other possible symptoms include lymph node enlargement, headache, bone pain, loss of appetite, fever, and fatigue. Thickened, grey or pink patches may develop on moist areas of skin and are highly infectious. Meningitis may also develop.

Following this symptomatic phase, the disease becomes latent for a few years, or sometimes indefinitely. A few untreated cases proceed, eventually, to a final stage characterized by widespread tissue destruction. This may be accompanied by cardiovascular syphilis, which affects the aorta and leads to aneurysm and heart-valve disease; neurosyphilis, with progressive brain damage and paralysis; and tabes dorsalis of the spinal cord.

Signs of congenital infection include a rash, persistent snuffles, bone abnormalities, jaundice, and enlargement of the liver and spleen. Keratitis, arthritis, a characteristic flat face, peg-shaped teeth, and mental handicap may appear later in childhood.

Diagnosis is by examination of chancre serum or by blood tests. All forms of syphilis are treated with antibacterial drugs. Organ damage already caused by the disease cannot be reversed.

Practising safer sex can help to prevent syphilis infection.

People with syphilis are infectious in the early stages but not in the latent and final stages.... syphilis




Recent Searches