Taxol Health Dictionary

Taxol: From 1 Different Sources


Taxus Baccata

Linn.

Family: Taxaceae.

Habitat: Temperate Himalayas, Khasi Hills and Manipur.

English: European Yew. Himalayan Yew is equated with Taxus wal- lichiana Zucc., synonym T. baccata Linn. subspecies wallichiana (Zucc.) Pilgoe, T. baccata Hook. f.

Ayurvedic: Thunera, Sthauneya, Sthauneyaka, Shukapushpa, Dhaatri-patra, Vikarna. (Not a substitute for Taalisapatra.)

Unani: Zarnab.

Siddha/Tamil: Taaleespatri Bhedam.

Folk: Birmi, Thuno.

Action: Herb—CNS depressant; reduces motor activity; analgesic, anticonvulsant. Leaf used in nervousness, epilepsy, hysteria, asthma, chronic bronchitis. Leaf and fruit—antispasmodic, sedative, emmenagogue.

Berry—used in chronic bronchitis. Taxol—antimitotic; also being tried for the treatment of severe drug-resistant human malaria. (Chem Abstr, 1994, 21, 124674 j.) (The taxol content in Himalayan Yew varied with season and location from 0.045-0.130%.)

The needles contain diterpene esters of taxane-type (mixture is known as taxine 0.6-2.0%). Taxine consists of 11 compounds of which only tax- ine A and B have been characterized. Taxol, the diterpene amide, is found active against ovarian cancer in humans. (clinical results showed 24-30% response). The ester alkaloids in higher doses are cardiotoxic.

Dried needles contain biflavonoids, including sotetsuflavone, sequoifla- vone, sciadopitysin, ginkgetin, kayafla- vone, amentoflavone, beta-sitosterol, heptacosanol and surcose.

The needles gave several phenolics. Betuloside (rhododendron) exhibited hepatoprotective activity against hepa- totoxins in rats.

The seeds are poisonous and contain taxine.

The aqueous extract of leaves showed a depressant effect on the central nervous system in rats.

The Ayurvedic Pharmacopoeia ofIn- dia attributed antirheumatic, anticatar- rhal, insecticidal and wound-healing properties to the dried needles of Himalayan Yew and indicated the use of the drug in powder form (1-3 g) in disorders due to vitiated blood, tumours, dermatosis and helminthiasis.

Dosage: Leaf—1-3 g powder. (API, Vol. III.) Leaf, bark—3-5 g powder. (CCRAS.)... taxus baccata

Cancer – Ovaries

Ovarian carcinoma. The fifth most common cause of death in women. Often together with bowel and breast cancers. Adeno-carcinoma. Prognosis poor because of delay in seeking medical advise.

Symptoms. Failing appetite, weight loss, flatulence, bowel symptoms, bladder disturbance, abdominal pain, clothes tight around the abdomen. The disease usually presents after the age of 45, users of contraceptives having a lower risk of development.

Risk of ovarian cancer has been related to women who consume too much animal fat and too little vegetable fat (JAM Nov. 1984). A similar risk is recorded in a report from Milan providing strong evidence of its relation to excessive coffee consumption.

Researchers at John Hopkin’s University, Baltimore, USA, report success with Taxol, extracted from the bark of the Pacific Yew Tree, given intravenously to 40 women with ovarian cancer resistant to other therapies, caused a 50 per cent decrease in size of the tumours. (New Scientist 1989, 1687, p37) Treatment. Should it be necessary to defer surgery or cytotoxic chemotherapy, any of the following alternatives may be taken with profit, or prescribed as secondary to primary treatment.

Tea. Equal parts: Agnus Castus, Gotu Kola, Red Clover. 1 heaped teaspoon to each cup boiling water; infuse 5-15 minutes. Drink freely.

Formula. Cramp bark 3; Liquorice 1; Thuja 1; Poke root half. Mix. Dose: Powders: 750mg (three 00 capsules or half a teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Thrice daily.

Vaginal pack. 8 parts Slippery Elm powder mixed with 1 part Thuja powder in a little water to form a paste; saturate tampon and insert.

Dr J. Christopher. For pre- and post-operative pain: Black Willow.

British Herbal Pharmacopoeia. Cramp bark for pain.

Diet. See: DIET – CANCER. Drinks of Violet leaf tea freely.

Supplements. Post-operative treatment should include Comfrey and Calcium to counter the loss of calcium on surgical removal, with possible brittle and broken bones in ageing women.

Note: When a potential lesion is found, a pelvic ultrasound scan may confirm.

Treatment by gynaecologist or oncologist. ... cancer – ovaries




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