Radical surgical procedures, usually combined with hormone therapy, that alter a person’s anatomical gender. Sex-change operations are performed on transsexuals (see transsexualism) and on infants whose external sex organs are neither completely male nor female (see genitalia, ambiguous).
A major surgical operation, usually coupled with the appropriate hormone treatment (see HORMONES), to change a person’s anatomical sex. The operation is done on transsexual individuals or in those whose sexual organs are neither totally female nor male. Male-to-female sex change is the more common. Such operations should not be performed without rigorous physical and mental assessment of the individual, and should be accompanied by extensive counselling. Some subjects make a satisfactory adjustment to the change of anatomical sex, while others may suffer serious psychological problems. Hormone therapy may need to be continued for life.
an unusual phenomenon in newborn babies characterized by transient red colour changes to half of the body, well demarcated at the midline. It is seen usually 2–5 days after birth and can last from 30 seconds to 20 minutes before fading away. It may recur when the infant is placed on his or her side as the intensity of the erythema appears to be gravity-dependent.... harlequin colour change
the commonest cause of *nephrotic syndrome in children and an important cause of this syndrome in adults. The condition is so named because of the apparent lack of abnormalities seen on light microscopy of biopsy samples. Changes can, however, be seen on electron microscopy, with effacement of the *podocyte foot processes along the glomerular basement membrane. It is postulated that minimal change disease is a T-cell disease and that *cytokine damage to the podocytes leads to loss of the selective filtering characteristics of the glomerulus. The condition usually responds to corticosteroids and has a good prognosis, but there is clinical overlap with primary *focal segmental glomerulosclerosis, which may have similar histological appearances in its early stages, tends not to respond to steroids, and is associated with a poor renal prognosis.... minimal change nephropathy
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