Oxygenated blood is supplied in the hepatic artery. The blood leaves the liver via a central vein in each lobule, which drains into the *hepatic vein. The liver is supplied by parasympathetic nerve fibres from the vagus nerve, and by sympathetic fibres from the solar plexus. The liver has a number of important functions. It synthesizes *bile, which drains into the *gall bladder before being released into the duodenum. The liver is an important site of metabolism of carbohydrates, proteins, and fats. It regulates the amount of blood sugar, converting excess glucose to *glycogen; it removes excess amino acids by breaking them down into ammonia and finally *urea; and it stores and metabolizes fats. The liver also synthesizes *fibrinogen and *prothrombin (essential blood-clotting substances) and *heparin, an anticoagulant. It forms red blood cells in the fetus and is the site of production of plasma proteins. It has an important role in the detoxification of poisonous substances and it breaks down worn out red cells and other unwanted substances, such as excess oestrogen in the male (see also Kupffer cells). The liver is also the site of *vitamin A synthesis; this vitamin is stored in the liver, together with vitamins B12, D, and K.
The liver is the site of many important diseases, including *hepatitis, *cirrhosis, amoebic *dysentery, *hydatid disease, and *hepatomas.... liver