The importation into Britain of opium is strictly regulated under the Dangerous Drugs Acts. Similar regulations govern the sale and distribution of any preparation of morphine or diamorphine (heroin) stronger than 1 part in
500. (See DEPENDENCE.)
Action The action of opium varies considerably, according to the source of the drug and the preparation used.
In small doses, opium produces a state of gentle excitement, the person ?nding their imagination more vivid, their thoughts more brilliant, and their power of expression greater than usual. This stage lasts for some hours, and is succeeded by languor. In medicinal doses this stage of excitement is short and is followed by deep sleep. When potentially poisonous doses are taken, sleep comes on quickly, and passes into coma and death (see OPIOID POISONING). The habitual use of opium produces great TOLERANCE, so that opium users require to take large quantities daily before experiencing its pleasurable effects. The need for opium also confers tolerance, so that people suffering great pain may take, with apparently little e?ect beyond dulling the pain, quantities which at another time would be dangerous.... opium
Habitat: Assam, North Bengal, Khasi and Jaintia Hills, sub Himalayan tracts of Uttar Pradesh and Himachal Pradesh and Western Ghats.
English: Canereed, Wild Ginger.Ayurvedic: Kebuka, Kembuka.Siddha/Tamil: Krrauvam, Malai Vasambu, Ven Kottam.Folk: Kebu.Action: Astringent, purgative, depurative, anti-inflammatory (used in gout, rheumatism; bronchitis, asthma, catarrhal fevers, dysuria), anthelmintic, antivermin, maggoticide, antifungal.
The rhizomes contain saponins— dioscin, gracillin and beta-sitosterol- beta-D-glucoside. The alkaloids show papaverine-like smooth-muscle-relaxant activity, cardiotonic activity like that of digitalis and antispasmodic,CNS-depressant, diuretic and hydro- choleretic activities. Saponins show significant anti-inflammatory and an- tiarthritic activity.The seeds also contain saponins and exhibit potent and sustained hypoten- sive and bradycardiac activities in dogs with low toxicity and without any haemolytic activity; also weak spasmolytic activity on isolated guinea-pig ileum.All parts of the plant yield steroidal sapogenin, diogenin (quantity varies from 0.32 to 4%).(Not to be confused with Kushtha of Indian medicine, Saussurea lappa.)... costus speciosusHabitat: Western Himalaya, from Kashmir to Garhwal, up to 3,000 m.
Action: Fern—diuretic, astringent; used for diseases of the urinary tract, infirmities of spleen, also for treating jaundice.
The plant contains caffeic acid, neo- hesperidin, kaempferol-3, 7-digluco- side, chlorogenic acid and quercetol- 3-glucoside. The leaves gave methyl esters of the acids—myristic, palmitic,Synonym: H. nepalense D. Don. H. lanatum Michx.Family: Umbelliferae; Apiaceae.Habitat: Chamba, Kulu, Jammu & Kashmir, Bushahr, Garhwal and Kumaon Hills.
English: Cowparsnip.Folk: Kaindal (Kashmir), Gandhraayana (Garhwal).Action: Fruit—stimulant, nervine tonic, spasmolytic. Heraclenin (active principle)—hypoprothrom- binaemic.
Essential oil from the fruits is moderately antimicrobial.Furanocoumarins present in the whole fruit and leaves are psoralen, xanthotoxin and bergapten. Roots also contain furanocoumarins.The fruits of H. concanense Dalz. contain a coumarin which is effective against dermatophytosis. The fruits of H. regins Wall. ex DC. are used for cough and bronchitis, also for urinary concretions in Siddha medicine. H. thomsoni C. B. Clarke (Kashmir and Himachal Pradesh) also contains a coumarin; the fruit showed nonspecific spasmolytic activity equipotent to papaverine.... hemidictyum ceterachHabitat: Near sea, especially on the West Coast.
English: Goat's Foot Creeper.Ayurvedic: Chhagalaantri, Mar- yaada-valli.Siddha/Tamil: Adambu, Attukkal, Musattalai.Action: Astringent, stomachic, laxative, antidiarrhoeal, antiemetic, analgesic. Leaf—diuretic, anti- inflammatory. Used in colic, prolapsus ani; externally in rheumatism. Essential oil of leaves— antagonistic to histamine. Leaf extract is used for different types of inflammations including injuries caused by poisonous jelly-fish.
Clinical trials have proved that an extract (IPA) inhibited the action of jelly-fish toxins. Its topical application inhibited carrageenan-induced paw and ear oedema induced by arachi- donic acid or ethyl phenylpropionate in rats. The crude extract of leaves also show inhibitory effect on prostaglan- din synthesis in vitro.Crude extract (IPA) of the leaves has also been shown to antagonize smooth muscle contraction induced by several agonists via non-specific mechanism. Antispasmodic isoprenoids, beta-damascenone and E-phytol have been isolated from the extract. The an- tispasmodic activity was found to be in the same range as that of papaverine.The alcoholic extract of leaves showed insulinogenic and hypogly- caemic activities in rats, comparable to the hypoglycaemic drug chlor- propamide.The leaves and seeds contain indole alkaloid. Plant also contains a steroid, an amide, pentatriacontane, triacon- tane, volatile oil and behenic, melissic, butyric and myristic acids.... ipomoea pes-capraeHabitat: Western Himalayas. Folk: Archa.
Action: Antispasmodic, muscle relaxant, antiseptic.
The rhizomes contain desoxyrha- pontigenin. The compound, like papaverine, exhibited smooth muscle relaxant activity in a wide variety of in vitro and in vivo tests. Aqueous alcoholic extract showed papaverine-like non-specific spasmolytic activity.The paste of fresh rhizomes is applied on burns, blisters and boils to prevent scar formation.... rheum webbianumHabitat: Native of Europe; grown in Jammu & Kashmir, Himachal Pradesh and Uttar Pradesh.
English: German Chamomile, Chamomile. German chamomile flower is equated with Matricaria recutita L. (synonym Chamomilla recutita L.) and Roman Chamomile flower with Anthemis nobilis L. (synonym Chamamaelum nobilis L.)Unani: Baabunaa.Action: Sedative, anticonvulsant, carminative, antispasmodic, analgesic, anti-inflammatory, antiseptic. See also Anthemis nobilis.
Key application (German Chamomile) ? In inflammatory diseases of the gastrointestinal tract and gastrointestinal spasm. Externally, in skin, mucous membrane and ano-genital inflammation and bacterial skin diseases. (German Commission E, The British Herbal Compendium.) As anti-inflammatory and anti- spasmodic. (The British Herbal Pharmacopoeia.)The flowers of German chamomile gave volatile oil up to about 2%, containing alpha-bisabolol up to 50%, azu- lenes including chamazulene, guiazu- line and matricine; flavonoids including apigenin and luteolin and their glycosides, patuletin and quercetin; spiroethers; coumarins; polysaccha- rides.The flowers are used as herbal tea for cough and cold and for promoting the flow of gastric secretion and bile. In chamomlile extracts, chamazulene has been found responsible for anti- inflammatory activity. Matricine and (-)-alpha-bisabolol also show anti- inflammatory and analgesic activity. Bisabolol exhibits ulceroprotective effect. Natural (-)-alpha-bisabolol has been shown to be significantly effective in healing burns; (-)-alpha-bisabolol, spiroethers and apigenin exhibit spasmolytic effect comparable with that of papaverine.The polysaccharides are immunos- timulating and activate macrophages and B lymphocytes; play an important role in wound healing.Crude aqueous extract of the plant has been reported to significantly delay the onset of convulsions and reduce mortality rate produced by picrotoxin experimentally.... matricaria chamomillaHabitat: Native to America; introduced in India.
English: Jamaica Dogwood.Action: Sedative, spasmolytic, analgesic, anti-inflammatory.
The bark gave several, isoflavonoids. Piscidone and piscerythrone exhibit spasmolytic activity. Piscidin glycoside and rotenone are toxic constituents.The bark is used for neuralgia, migraine and insomnia in South America and West Indies.In some in vitro tests, the root bark's extract exhibited antispasmodic effects as strong as papaverine's (Natural Medicines Comprehensive Database, 2007.)... piscidia piscipulaHabitat: Kashmir and throughout the plains of North India; cultivated in gardens.
English: Corn Poppy, Red Poppy.Ayurvedic: Rakta Posta.Siddha/Tamil: Sivappu, Kasakasa.Folk: Laal Posta, Laal Kaskas.Action: Latex from capsules— narcotic. Petal—expectorant, antitussive, sudorific. Used for diseases of the respiratory tract, for disturbed sleep and as a sedative for the relief of pain. (Included among unapproved herbs by German Commission E.)
The petals contain cyanidine derivatives. An alkaloid rhoeadine is present in leaves and flowers (0.031%), unripe capsules (0.035%) and in rootsFamily: Papaveraceae.Habitat: Native to Asia; now grown in Uttar Pradesh, Punjab, Rajasthan and Madhya Pradesh.
English: Opium Poppy.Ayurvedic: Ahiphena, Aaphuuka. Post-daanaa (seed).Unani: Afyum. Tukhm-e- khashkhaash (seed).Siddha/Tamil: Kasakasa (seeds).Action: Opium is obsolete as a drug. Narcotic, sedative, hypnotic, analgesic, sudorific, anodyne, antispasmodic. Crushed poppyheads were in use as a topical poultice for crippling pain in terminal diseases. Poppy seed—nutritive, demulcent, emollient, spasmolytic, devoid of narcotic properties. Specific against obstinate constipation, also used in catarrh of the bladder. Poppy seed oil is also free from narcotic properties. Used against diarrhoea, dysentery and scalds.
Opium contains isoquinoline alkaloids; the major one is morphine with narcotine, codeine, papaverine and thebaine. Poppy seeds, used in Indian medicine, do not contain alkaloids. The seeds contain thiamine 420, riboflavin 49, folic acid 30, pantothenic acid 2667 and niacin 1877 mcg/100 g. The seed oil (from Turkey) contains gamma-tocopherol 220, alpha-toco- pherol 40 and beta-tocopherol 20 mcg/ 100 g. Some low-molecular proteins (15% of total protein) have been isolated, along with cysteine, glutamic acid and arginine. The seeds yield a fatty oil (45%) containing palmitic, stearic, oleic, linoleic and linolenic acids.The extract of seeds showed highly significant antisecretory (antidiarr- hoeal activity) against E. coli entero- toxin-induced secretory responses in experimental animals.The triglycerides isolated from seeds showed anti-tumour activity against Ehrlichs ascites in mice.The aqueous extract of seeds showed marked hypoglycaemic activity when administered to glucose-loaded and al- loxan diabetic rats.The seeds were found to increase the activity of carcinogen detoxifying enzyme, glutathione-S-transferase by more than 78% in the stomach, liver and oesophagus in mice.Following Papaver sp. are found in India:P. argemone Linn. (indigenous to the Mediterranean region; commonly grown in gardens in India) contains 0.15% of alkaloids including rhoeadine, protopine, and anthocyanins. Petals are sudorific.P dubium Linn. (North-western Himalaya form Kashmir to Garhwal; as a winter weed in North Indian plains) contains rhoeagenine as the principal alkaloid, besides rhoeadine, protopine. Petals contain cyanidin B and pelargonidin C. Petals are sudorific.P. hybridum Linn. (gardens of Punjab and Uttar Pradesh) is diaphoretic (petals). Plant latex contains alkaloids including berberine, coptisine, pahybrine, papaverrubines A, B, D and E and sanguinarine. Plant also gave glaucine and glucamine.P. nudicaule Linn. (Gulmarg, Kashmir, at altitudes of 3,300-3,600 m), known as Iceland Poppy, gave alkaloids including papaverrubines B and D; leave gave cyanogenic glycosides including dhurrin and triglochinin. The flower and fruit are mild diaphoretic.P. orientale Linn. (indigenous to Mediterranean region; grown in Indian gardens), known as Oriental Poppy, contains 0.16% of alkaloids including thebaine, isothebane, protopine, glaucidine and oripavine. Latex from poppy capsule is narcotic.... papaver somniferumHabitat: Tropical Himalayas, from Kumaon eastwards to Assam, Khasi hills and throughout the Western Peninsula.
English: Wild Orange tree, Forest Pepper.Ayurvedic: Kanchana.Siddha/Tamil: Kattu Milagu, Milagaranai.Folk: Jangali Kaali-mirch, Kanja.Action: Whole plant—febrifuge, diuretic, Leaves—antispasmodic. Rootbark—antipyretic, diaphoretic, antiperiodic.
Used as a tonic during convalescence and constitutional debility. (The rootbark was used medicinally in the past in Europe under the name Lopez Root or Cortex Radicis as an antimalarial drug.)Unripe fruits and roots are included in liniments used for rheumatism.The rootbark contains alkaloids, including toddaline, toddalinine, skim- mianine. The root gave coumarins, including toddanol, toddanone, todda- sin, pimpinellin, iso-pimpinellin and toddalolactone.Alkaloid toddaline is irritant to the mucous membrane, bronchi, intestines and the bladder.Ethanolic extract of var. obtusifolia Gemble, found in the Nilgiris, Tamil Nadu, exhibited spasmolytic activity.Among the coumarins, chlorocou- marin is the most important active principle and can be used an alternative for papaverine obtained from poppy.... toddalia asiatica
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