Normoblast Health Dictionary

The process by which ERYTHROCYTES or red blood cells are produced. The initiating cell is the haemopoietic stem cell from which an identi?able proerythroblast develops. This goes through several stages as a normoblast before losing its nucleus to become an erythrocyte. This process takes place in the blood-forming bone-marrow tissue.... erythropoeisis

n. any of a series of nucleated cells (see normoblast; proerythroblast) that pass through a succession of stages of maturation to form red blood cells (*erythrocytes). Erythroblasts are normally present in the blood-forming tissue of the bone marrow, but they may appear in the circulation in a variety of diseases (see erythroblastosis). See also erythropoiesis.... erythroblast

n. the process of red blood cell (*erythrocyte) production, which normally occurs in the blood-forming tissue of the *bone marrow. The ultimate precursor of the red cell is the *haemopoietic stem cell, but the earliest precursor that can be identified microscopically is the *proerythroblast. This divides and passes through a series of stages of maturation termed respectively early, intermediate, and late *normoblasts, the latter finally losing its nucleus to become a mature red cell. See also haemopoiesis.... erythropoiesis

n. an abnormal form of any of the cells (*normoblasts) that form a series of precursors of red blood cells. Macronormoblasts are unusually large but have normal nuclei (compare megaloblast); they are seen in certain anaemias in which red cell production is impaired.... macronormoblast