n. a drug administered to prevent the toxic effects of *alkylating agents, particularly *ifosfamide and *cyclophosphamide, on the bladder. It binds with the toxic metabolite acrolein in the urine.
n. an *alkylating agent used to treat a variety of cancers, including chronic lymphocytic leukaemia, lymphomas, and solid tumours, often in combination with other *cytotoxic drugs. It also has *immunosuppressant properties and is used in treating conditions, notably rheumatoid arthritis, requiring a reduced immune response. Common side-effects are nausea, vomiting, and – particularly at high doses – hair loss. See also mesna.... cyclophosphamide
n. a *cytotoxic drug (an *alkylating agent) used in the treatment of malignant disease, particularly sarcomas, testicular tumours, and lymphomas. Side-effects include nausea, vomiting, alopecia, and haemorrhagic cystitis; concomitant administration of *mesna is recommended to prevent cystitis.... ifosfamide
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