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n. the body’s ability to resist infection, afforded by the presence of circulating *antibodies and white blood cells. Healthy individuals protect themselves by means of physical barriers, phagocytic cells, *natural killer cells, and various blood-borne molecules. All of these mechanisms are present prior to exposure to infectious agents and are part of natural (or innate) immunity. Antibodies are manufactured specifically to deal with the antigens associated with different diseases as they are encountered. Active immunity arises when the body’s own cells produce, and remain able to produce, appropriate antibodies following an attack of a disease or deliberate stimulation (see immunization). Passive immunity, which is only short-lived, is provided by injecting ready-made antibodies in *antiserum taken from another person or an animal already immune. Babies have passive immunity, conferred by antibodies from the maternal blood and *colostrum, to common diseases for several weeks after birth. See also immune response.

Oxford | Concise Colour Medical Dictionary | Jonathan Law, Elizabeth Martin

The ability to resist infection and to heal. The process may involve acquired immunity, (the ability to learn and remember a specific infectious agent), or innate immunity (the genetically programmed system of responses that attack, digest, remove, and initiate inflammation and tissue healing).

Medical Dictionary | Health Dictionary

The body’s defence against foreign substances such as bacteria, viruses and parasites. Immunity also protects against drugs, toxins and cancer cells. It is partly non-speci?c – that is, it does not depend on previous exposure to the foreign substance. For example, micro-organisms are engulfed and inactivated by polymorphonuclear LEUCOCYTES as a ?rst line of defence before speci?c immunity has developed.

Acquired immunity depends upon the immune system recognising a substance as foreign the ?rst time it is encountered, storing this information so that it can mount a reaction the next time the substance enters the body. This is the usual outcome of natural infection or prophylactic IMMUNISATION. What happens is that memory of the initiating ANTIGEN persists in selected lymphocytes (see LYMPHOCYTE). Further challenge with the same antigen stimulates an accelerated, more vigorous secondary response by both T- and B-lymphocytes (see below). Priming the immune system in this manner forms the physiological basis for immunisation programmes.

Foreign substances which can provoke an immune response are termed ‘antigens’. They are usually proteins but smaller molecules such as drugs and chemicals can also induce an immune response. Proteins are taken up and processed by specialised cells called ‘antigenpresenting cells’, strategically sited where microbial infection may enter the body. The complex protein molecules are broken down into short amino-acid chains (peptides – see PEPTIDE) and transported to the cell surface where they are presented by structures called HLA antigens (see HLA SYSTEM).

Foreign peptides presented by human leucocyte antigen (HLA) molecules are recognised by cells called T-lymphocytes. These originate in the bone marrow and migrate to the THYMUS GLAND where they are educated to distinguish between foreign peptides, which elicit a primary immune response, and self-antigens (that is, constituents of the person themselves) which do not. Non-responsiveness to self-antigens is termed ‘tolerance’ (see AUTOIMMUNITY). Each population or clone of T-cells is uniquely responsive to a single peptide sequence because it expresses a surface molecule (‘receptor’) which ?ts only that peptide. The responsive T-cell clone induces a speci?c response in other T-and B-lymphocyte populations. For example, CYTOTOXIC T-cells penetrate infected tissues and kill cells which express peptides derived from invading micro-organisms, thereby helping to eliminate the infection.

B-lymphocytes secrete ANTIBODIES which are collectively termed IMMUNOGLOBULINS (Ig)

– see also GAMMA-GLOBULIN. Each B-cell population (clone) secretes antibody uniquely speci?c for antigens encountered in the blood, extracellular space, and the LUMEN of organs such as the respiratory passages and gastrointestinal tract.

Antibodies belong to di?erent Ig classes; IgM antibodies are synthesised initially, followed by smaller and therefore more penetrative IgG molecules. IgA antibodies are adapted to cross the surfaces of mucosal tissues so that they can adhere to organisms in the gut, upper and lower respiratory passages, thereby preventing their attachment to the mucosal surface. IgE antibodies also contribute to mucosal defence but are implicated in many allergic reactions (see ALLERGY).

Antibodies are composed of constant portions, which distinguish antibodies of di?erent class; and variable portions, which confer unique antigen-binding properties on the product of each B-cell clone. In order to match the vast range of antigens that the immune system has to combat, the variable portions are synthesised under the instructions of a large number of encoding GENES whose products are assembled to make the ?nal antibody. The antibody produced by a single B-cell clone is called a monoclonal antibody; these are now synthesised and used for diagnostic tests and in treating certain diseases.

Populations of lymphocytes with di?erent functions, and other cells engaged in immune responses, carry distinctive protein markers. By convention these are classi?ed and enumerated by their ‘CD’ markers, using monoclonal antibodies speci?c for each marker.

Immune responses are in?uenced by cytokines which function as HORMONES acting over a short range to accelerate the activation and proliferation of other cell populations contributing to the immune response. Speci?c immune responses collaborate with nonspeci?c defence mechanisms. These include the COMPLEMENT SYSTEM, a protein-cascade reaction designed to eliminate antigens neutralised by antibodies and to recruit cell populations which kill micro-organisms.

Herbal Medical | Health Dictionary

The body’s ability to resist and overcome infection and cancer.

Dictionary of Tropical Medicine | Health Dictionary

A state of protection against disease through the activities of the immune system. Innate immunity is present from birth; acquired (adaptive) immunity develops either through exposure to invading microorganisms or through immunization.

BMA Medical Dictionary | The British Medical Association


Immunity | Health Encyclopedia

The keywords of this medical terms: Immunity

Autoimmunity

The state of having acquired an immunologic memory that says a normal cell membrane is “other”, and having forming antibody responses against it. A viral infection or organic chemical (hapten) may have started the response, but surviving healthy cells may have so close a charge pattern (epitope) that acquired immunity keeps on as if the cell was still “other”. Any physical stress that causes the target tissue to become inflamed or replicate rapidly to heal can restimulate the auto-immune response.... Herbal Medical

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Herbal Medical

Autoimmunity

Autoimmunity is a reaction to an individual’s own tissues (self-antigens – see ANTIGEN) to which tolerance has been lost (see IMMUNITY). Autoantibodies are not necessarily harmful and are commonly encountered in healthy persons.

Autoimmune disease ensues when the immune system attacks the target cells of the autoimmune reaction.... Medical Dictionary

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Medical Dictionary

Autoimmunity

n. a disorder of the body’s defence mechanisms in which an *immune response is generated against components or products of its own tissues, treating them as foreign material and attacking them. See autoimmune disease; immunity.... Oxford | Concise Colour Medical Dictionary

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Oxford | Concise Colour Medical Dictionary

Cell-mediated Immunity

A defence mechanism involving the coordinated activity of two subpopulations of TLymphocytes, helper T-Cells and killer T-Cells. Helper T-Cells produce a variety of substances that stimulate and regulate other participants in the immune response. Killer T-Lymphocytes destroy cells in the body that bear foreign antigens (e.g. cells that are infected with viruses or other microorganisms).... Dictionary of Tropical Medicine

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Dictionary of Tropical Medicine

Herd Immunity

A level of immunity found in a community of animals/humans and related to a particular infection to which the community has been exposed.... Dictionary of Tropical Medicine

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Dictionary of Tropical Medicine

Herd Immunity

the immunity of a group, community, or population to an infectious disease as a result of mass vaccination. The higher the percentage of the population vaccinated, the greater will be the resistance to the spread of infection within the population.... Oxford | Concise Colour Medical Dictionary

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Oxford | Concise Colour Medical Dictionary