hydroxymethylglutaryl coenzyme A reductase: the key rate-limiting enzyme that is involved in the production of cholesterol in the liver. Inhibition of its action is the mechanism by which the *statin group of lipid-lowering agents work.
any of various drugs that interfere with the conversion of folate to its active form in the body. They include *pyrimethamine, *trimethoprim, and *methotrexate. When such drugs are necessary, folate deficiency is treated with *folinic acid rather than folic acid.... dihydrofolate reductase inhibitor
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