Hivan Health Dictionary

Hivan: From 1 Different Sources


human immunodeficiency virus-associated nephropathy: a condition associated with HIV infection. The patient usually presents with nephrotic-range proteinuria (see nephrotic syndrome) with microscopic haematuria, without oedema but with a rapid decline in renal function. Enlargement of the kidneys on ultrasound examination is a common finding, and HIVAN may precede other manifestations of HIV infection. Typical renal pathological findings are of a collapsing form of *focal segmental glomerulosclerosis. The clinical course is usually one of rapid decline in renal function.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Nephropathy

n. disease of the kidney. See also Balkan nephropathy; Berger’s nephropathy; cast nephropathy; Chinese herb nephropathy; diabetic nephropathy; HAN; HIVAN; hypercalcaemic nephropathy; hypokalaemic nephropathy; membranous nephropathy; minimal change nephropathy; sickle-cell nephropathy.... nephropathy

Podocyte

n. an epithelial cell in the *glomerulus that spreads over the capillary basement membrane and has branching tentacle-like processes that interdigitate with adjacent cells. The podocytes leave gaps or thin filtration slits. The slits are covered by slit diaphragms, which are composed of a number of cell-surface proteins including *nephrin, podocalyxin, and P-cadherin, which ensure that large molecules, such as albumin and gammaglobulin, are not filtered. Podocytes are damaged in *minimal change nephropathy and a major target of injury in *HIVAN.... podocyte



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