Gene therapy is currently used to treat disorders caused by a fault in a single recessive gene, when the defect can remedied by introducing a normal ALLELE. Treating disorders caused by dominant genes is more complicated. CYSTIC FIBROSIS is an example of a disease caused by a recessive gene, and clinical trials are taking place on the e?ectiveness of using LIPOSOMES to introduce the normal gene into the lungs of someone with the disorder. Trials are also underway to test the e?ectiveness of introducing tumour-suppressing genes into cancer cells to check their spread.
Gene therapy was ?rst used in 1990 to treat an American patient. Eleven European medical research councils (including the UK’s) recommended in 1988 that gene therapy should be restricted to correcting disease or defects, and that it should be limited to somatic cells. Interventions in germ-line cells (the sperm and egg) to e?ect changes that would be inherited, though technically feasible, is not allowed (see CLONING; HUMAN GENOME).... gene therapy
A physical examination is usually performed, including measurement of body fat, height, and weight. Blood and urine tests may be done, including an analysis of blood cholesterol. The performance of the heart is measured by taking the pulse before, during, and after aerobic exercise. Another test involves measuring a person’s overall performance in a standard exercise. (See also aerobics; exercise.)... fitness testing
Blood samples are taken from the child, from the suspected father, and sometimes from the mother.
The samples are tested for blood groups, histocompatibility antigens, and similarities in DNA.
Genetic fingerprinting provides the most decisive result.... paternity testing