Diazepam Health Dictionary

Diazepam: From 3 Different Sources


One of the benzodiazepine drugs, used mainly for the short-term treatment of anxiety and insomnia. It is also prescribed as a muscle-relaxant drug, as an anticonvulsant drug in the emergency treatment of epilepsy, and to treat alcohol withdrawal symptoms. It may also be given intravenously to produce sedation in people undergoing certain procedures, such as endoscopy.

Diazepam may cause drowsiness, dizziness, and confusion; therefore driving and hazardous work should be avoided. Diazepam can be habit-forming.

Health Source: BMA Medical Dictionary
Author: The British Medical Association
See TRANQUILLISERS; BENZODIAZEPINES.
Health Source: Medical Dictionary
Author: Health Dictionary
n. a long-acting *benzodiazepine used for the short-term relief of acute anxiety and insomnia and in the treatment of delirium tremens, status epilepticus, and febrile convulsions; it is also used as a *premedication. Diazepam is administered by mouth, injection, or rectally and can cause dependence; side-effects include drowsiness and lethargy, confusion, and muscle weakness.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Anticonvulsants

Drugs that reduce or prevent the severity of an epileptic convulsion or seizure (see EPILEPSY). The nature of the ?t, and the patient’s reaction to it, in?uences the type of anticonvulsant used. Anticonvulsants inhibit the high level of electrical activity in the brain that causes the ?t. Among regularly used anticonvulsants are carbamazepine, sodium valproate, clonazopam, lamotrigine, gabapentin, vigabatrin, and topiramate. Older drugs such as phenytoin and primidone remain useful in some patients. Intravenous anticonvulsants, such as diazepam, are used for rapid control of epileptic status.... anticonvulsants

Eclampsia

A rare disorder in which convulsions occur during late pregnancy (see also PREGNANCY AND LABOUR – Increased blood pressure). This condition occurs in around 50 out of every 100,000 pregnant women, especially in the later months and at the time of delivery, but in a few cases only after delivery has taken place. The cause is not known, although cerebral OEDEMA is thought to occur. In practically all cases the KIDNEYS are profoundly affected. E?ective antenatal care should identify most women at risk of developing eclampsia.

Symptoms Warning symptoms include dizziness, headache, oedema, vomiting, and the secretion of albumin (protein) in the urine. These are normally accompanied by a rise in blood pressure, which can be severe. Preeclamptic symptoms may be present for some days or weeks before the seizure takes place, and, if a woman is found to have these during antenatal care, preventive measures must be taken. Untreated, CONVULSIONS and unconsciousness are very likely, with serious migraine-like frontal headache and epigastric pain the symptoms.

Treatment Prevention of eclampsia by dealing with pre-eclamptic symptoms is the best management, but even this may not prevent convulsions. Hospital treatment is essential if eclampsia develops, preferably in a specialist unit. The treatment of the seizures is that generally applicable to convulsions of any kind, with appropriate sedatives given such as intravenous DIAZEPAM. HYDRALLAZINE intravenously should also be administered to reduce the blood pressure. Magnesium sulphate given intramuscularly sometimes helps to control the ?ts. The baby’s condition should be monitored throughout.

Urgent delivery of the baby, if necessary by CAESAREAN SECTION, is the most e?ective ‘treatment’ for a mother with acute eclampsia. (See PREGNANCY AND LABOUR.)

Women who have suffered from eclampsia are liable to suffer a recurrence in a further preganancy. Careful monitoring is required. There is a self-help organisation, Action on Pre-eclampsia (APEC), to advise on the condition.... eclampsia

Ecstasy

Ecstasy refers to a morbid mental condition, associated with an extreme sense of wellbeing, with a feeling of rapture, and temporary loss of self-control. It often presents as a form of religious obsession, with a feeling of direct communication with God, saintly voices and images being perceived. In milder cases the patient may preach as though with a divine mission to help others. Ecstasy may occur in happiness PSYCHOSIS, SCHIZOPHRENIA, certain forms of EPILEPSY, and abnormal personalities.

The term is also a street drug name for an amphetamine derivative, 3, 4-methylenedioxymethamphetamine or MDMA, increasingly used as a ‘recreational’ drug. It is classi?ed as a class A drug under the Misuse of Drugs Act 1971. MDMA is structurally similar to endogenous CATECHOLAMINES and produces central and peripheral sympathetic stimulation of alpha and beta ADRENERGIC RECEPTORS. It is taken into nerve terminals by the serotonin transporter and causes release of the NEUROTRANSMITTER substances serotonin and dopamine. Following this, SEROTONIN depletion is prolonged. As serotonin plays a major part in mood control, this leads to the characteristic ‘midweek depression’ experienced by MDMA users.

Several fatalities in young people have been attributed to adverse reactions resulting from MDMA use/abuse and possibly accompanying alcohol consumption. The principal effects are increase in pulse, blood pressure, temperature and respiratory rate. Additional complications such as cardiac ARRHYTHMIA, heatstroke-type syndrome, HYPONATRAEMIA and brain haemorrhage may occur. There is also concern over possible effects on the mental concentration and memory of those using ecstasy.

Management of patients who get to hospital is largely symptomatic and supportive but may include gastric decontamination, and use of DIAZEPAM as the ?rst line of treatment as it reduces central stimulation which may also reduce TACHYCARDIA, HYPERTENSION and PYREXIA.... ecstasy

Grapefruit

(Ugli fruit)

Nutritional Profile Energy value (calories per serving): Low Protein: Low Fat: Low Saturated fat: Low Cholesterol: None Carbohydrates: High Fiber: Moderate Sodium: Low Major vitamin contribution: Vitamin A, vitamin C Major mineral contribution: Potassium

About the Nutrients in This Food Grapefruit and ugli fruit (a cross between the grapefruit and the tangerine) have moderate amounts of dietary fiber and, like all citrus fruits, are most prized for their vitamin C. Pink or red grapefruits have moderate amounts of vitamin A. One-half medium (four-inch diameter) pink grapefruit has 1.4 g dietary fiber, 1,187 IU vitamin A (51 percent of the R DA for a woman, 40 percent of the R DA for a man), and 44 mg vitamin C (59 percent of the R DA for a woman, 49 percent of the R DA for a man). One half medium (3.75-inch diameter) white grapefruit has 1.3 g dietary fiber, 39 IU vitamin A (2 percent of the R DA for a woman, 1 percent of the R DA for a man), and 39 mg vitamin C (52 percent of the R DA for a woman, 43 percent of the R DA for a man). Pink and red grapefruits also contain lycopene, a red carotenoid (plant pigment), a strong antioxidant that appears to lower the risk of cancer of the prostate. The richest source of lycopene is cooked tom atoes.

The Most Nutritious Way to Serve This Food Fresh fruit or fresh-squeezed juice.

Buying This Food Look for: Firm fruit that is heavy for its size, which means that it will be juicy. The skin should be thin, smooth, and fine-grained. Most grapefruit have yellow skin that, depending on the variety, may be tinged with red or green. In fact, a slight greenish tint may mean that the grapefruit is high in sugar. Ugli fruit, which looks like misshapen, splotched grapefruit, is yellow with green patches and bumpy skin. Avoid: Grapefruit or ugli fruit with puff y skin or those that feel light for their size; the flesh inside is probably dry and juiceless.

Storing This Food Store grapefruit either at room temperature (for a few days) or in the refrigerator. Refrigerate grapefruit juice in a tightly closed glass bottle with very little air space at the top. As you use up the juice, transfer it to a smaller bottle, again with very little air space at the top. The aim is to prevent the juice from coming into contact with oxygen, which destroys vitamin C. (Most plastic juice bottles are oxygen-permeable.) Properly stored and protected from oxygen, fresh grapefruit juice can hold its vitamin C for several weeks.

Preparing This Food Grapefruit are most flavorful at room temperature, which liberates the aromatic molecules that give them their characteristic scent and taste. Before cutting into the grapefruit, rinse it under cool running water to flush debris off the peel. To section grapefruit, cut a slice from the top, then cut off the peel in strips—starting at the top and going down—or peel it in a spiral fashion. You can remove the bitter white membrane, but some of the vitamin C will go with it. Finally, slice the sections apart. Or you can simply cut the grapefruit in half and scoop out the sections with a curved, serrated grapefruit knife.

What Happens When You Cook This Food Broiling a half grapefruit or poaching grapefruit sections reduces the fruit’s supply of vitamin C, which is heat-sensitive.

How Other Kinds of Processing Affect This Food Commercially prepared juices. How well a commercially prepared juice retains its vitamin C depends on how it is prepared, stored, and packaged. Commercial flash-freezing preserves as much as 95 percent of the vitamin C in fresh grapefruit juices. Canned juice stored in the refrigerator may lose only 2 percent of its vitamin C in three months. Prepared, pasteurized “fresh” juices lose vitamin C because they are sold in plastic bottles or waxed-paper cartons that let oxygen in. Commercially prepared juices are pasteurized to stop the natural enzyme action that would otherwise turn sugars to alcohols. Pasteurization also protects juices from potentially harmful bacterial and mold contamination. Following several deaths attributed to unpas- teurized apple juices containing E. coli O157:H7, the FDA ruled that all fruit and vegetable juices must carry a warning label telling you whether the juice has been pasteurized. Around the year 2000, all juices must be processed to remove or inactivate harmful bacteria.

Medical Uses and/or Benefits Antiscorbutic. All citrus fruits are superb sources of vitamin C, the vitamin that prevents or cures scurvy, the vitamin C-deficiency disease. Increased absorption of supplemental or dietary iron. If you eat foods rich in vitamin C along with iron supplements or foods rich in iron, the vitamin C will enhance your body’s ability to absorb the iron. Wound healing. Your body needs vitamin C in order to convert the amino acid proline into hydroxyproline, an essential ingredient in collagen, the protein needed to form skin, ten- dons, and bones. As a result people with scurvy do not heal quickly, a condition that can be remedied with vitamin C, which cures the scurvy and speeds healing. Whether taking extra vitamin C speeds healing in healthy people remains to be proved. Possible inhibition of virus that causes chronic hepatitis C infection. In Januar y 2008, research- ers at Massachusetts General Hospital Center for Engineering in Medicine (Boston) published a report in the medical journal Hepatology detailing the effect of naringenin, a compound in grapefruit, on the behavior of hepatitis viruses in liver cells. In laborator y studies, naringenin appeared to inhibit the ability of the virus to multiply and/or pass out from the liver cells. To date, there are no studies detailing the effect of naringenin in human beings with hepatitis C.

Adverse Effects Associated with This Food Contact dermatitis. The essential oils in the peel of citrus fruits may cause skin irritation in sensitive people.

Food/Drug Interactions Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen and others. Taking aspirin or NSAIDs with acidic foods such as grapefruit may intensif y the drug’s ability to irritate your stomach and cause gastric bleeding. Antihistamines, anticoagulants, benzodiazepines (tranquilizers or sleep medications), calcium channel blockers (blood pressure medication), cyclosporine (immunosuppressant drug used in organ transplants), theophylline (asthma drug). Drinking grapefruit juice with a wide variety of drugs ranging from antihistamines to blood pressure medication appears to reduce the amount of the drug your body metabolizes and eliminates. The “grapefruit effect” was first identified among people taking the antihypertensive drugs felodipine (Plendil) and nifedip- ine (Adalat, Procardia). It is not yet known for certain exactly what the active substance in the juice is. One possibility, however, is bergamottin, a naturally occurring chemical in grapefruit juice known to inactivate cytochrome P450 3A4, a digestive enzyme needed to convert many drugs to water-soluble substances you can flush out of your body. Without an effective supply of cytochrome P450 3A4, the amount of a drug circulating in your body may rise to dangerous levels. Reported side effects include lower blood pressure, increased heart rate, headache, flushing, and lightheadedness. Some Drugs Known to Interact with Grapefruit Juice* Drug Class  Generic (Brand name) Antianxiety drug  Diazepam ( Valium) Antiarrhythmics  Amiodarone (Cordarone) Blood-pressure drugs  Felodipine (Plendil), nicardipine (Cardene), nimodipine (Nimotop), nisoldipine (Sular), verapamil ( Verelan) Cholesterol-lowering drugs  Atorvastatin (Lipitor), lovastatin (Mevacor), simvastatin (Zocor), simvastatin/ezetimibe ( Vytorin) Immune Suppressants  Cyclosporine (Neoral), tacrolimus (Prograf ) Impotence Drug  Sildenafil ( Viagra) Pain Medication Methadone (Dolophine, Methadose) * This list may grow as new research appears.... grapefruit

Mental Illness

De?ned simply, this is a disorder of the brain’s processes that makes the sufferer feel or seem ill, and may prevent that person from coping with daily life. Psychiatrists – doctors specialising in diagnosing and treating mental illness – have, however, come up with a range of much more complicated de?nitions over the years.

Psychiatrists like to categorise mental illnesses because mental signs and symptoms do occur together in clusters or syndromes, each tending to respond to certain treatments. The idea that illnesses can be diagnosed simply by recognising their symptom patterns may not seem very scienti?c in these days of high technology. For most common mental illnesses, however, this is the only method of diagnosis; whatever is going wrong in the brain is usually too poorly understood and too subtle to show up in laboratory tests or computed tomography scans of the brain. And symptom-based definitions of mental illnesses are, generally, a lot more meaningful than the vague lay term ‘nervous breakdown’, which is used to cover an attack of anything from AGORAPHOBIA to total inability to function.

There is still a lot to learn about the workings of the brain, but psychiatry has developed plenty of practical knowledge about the probable causes of mental illness, ways of relieving symptoms, and ways of aiding recovery. Most experts now believe that mental illnesses generally arise from di?erent combinations of inherited risk and psychological STRESS, sometimes with additional environmental exposure – for example, viruses, drugs or ALCOHOL.

The range of common mental illnesses includes anxiety states, PHOBIA, DEPRESSION, alcohol and drug problems, the EATING DISORDERS anorexia and bulimia nervosa, MANIC DEPRESSION, SCHIZOPHRENIA, DEMENTIA, and a group of problems related to coping with life that psychiatrists call personality disorders.

Of these mental illnesses, dementia is the best understood. It is an irreversible and fatal form of mental deterioration (starting with forgetfulness and eventually leading to severe failure of all the brain’s functions), caused by rapid death of brain cells and consequent brain shrinkage. Schizophrenia is another serious mental illness which disrupts thought-processes, speech, emotions and perception (how the brain handles signals from the ?ve senses). Manic depression, in which prolonged ‘highs’ of extremely elevated mood and overexcitement alternate with abject misery, has similar effects on the mental processes. In both schizophrenia and manic depression the sufferer loses touch with reality, develops unshakeable but completely unrealistic ideas (delusions), and hallucinates (vividly experiences sensations that are not real, e.g. hears voices when there is nobody there). This triad of symptoms is called psychosis and it is what lay people, through fear and lack of understanding, sometimes call lunacy, madness or insanity.

The other mental illnesses mentioned above are sometimes called neuroses. But the term has become derogatory in ordinary lay language; indeed, many people assume that neuroses are mild disorders that only affect weak people who cannot ‘pull themselves together’, while psychoses are always severe. In reality, psychoses can be brief and reversible and neuroses can cause lifelong disability.

However de?ned and categorised, mental illness is a big public-health problem. In the UK, up to one in ?ve women and around one in seven men have had mental illness. About half a million people in Britain suffer from schizophrenia: it is three times commoner than cancer. And at any one time, up to a tenth of the adult population is ill with depression.

Treatment settings Most people with mental-health problems get the help they need from their own family doctor(s), without ever seeing a psychiatrist. General practictitioners in Britain treat nine out of ten recognised mental-health problems and see around 12 million adults with mental illness each year. Even for the one in ten of these patients referred to psychiatrists, general practitioners usually handle those problems that continue or recur.

Psychiatrists, psychiatric nurses, social workers, psychologists, counsellors and therapists often see patients at local doctors’ surgeries and will do home visits if necessary. Community mental-health centres – like general-practice health centres but catering solely for mental-health problems – o?er another short-cut to psychiatric help. The more traditional, and still more common, route to a psychiatrist for many people, however, is from the general practititioner to a hospital outpatient department.

Specialist psychiatric help In many ways, a visit to a psychiatrist is much like any trip to a hospital doctor – and, indeed, psychiatric clinics are often based in the outpatient departments of general hospitals. First appointments with psychiatrists can last an hour or more because the psychiatrist – and sometimes other members of the team such as nurses, doctors in training, and social workers – need to ask lots of questions and record the whole consultation in a set of con?dential case notes.

Psychiatric assessment usually includes an interview and an examination, and is sometimes backed up by a range of tests. The interview begins with the patient’s history – the personal story that explains how and, to some extent, why help is needed now. Mental-health problems almost invariably develop from a mixture of causes – emotional, social, physical and familial – and it helps psychiatrists to know what the people they see are normally like and what kind of lives they have led. These questions may seem unnecessarily intrusive, but they allow psychiatrists to understand patients’ problems and decide on the best way to help them.

The next stage in assessment is the mental-state examination. This is how psychiatrists examine minds, or at least their current state. Mental-state examination entails asking more questions and using careful observation to assess feelings, thoughts and mental symptoms, as well as the way the mind is working (for example, in terms of memory and concentration). During ?rst consultations psychiatrists usually make diagnoses and explain them. The boundary between a life problem that will clear up spontaneously and a mental illness that needs treatment is sometimes quite blurred; one consultation may be enough to put the problem in perspective and help to solve it.

Further assessment in the clinic may be needed, or some additional tests. Simple blood tests can be done in outpatient clinics but other investigations will mean referral to another department, usually on another day.

Further assessment and tests

PSYCHOLOGICAL TESTS Psychologists work in or alongside the psychiatric team, helping in both assessment and treatment. The range of psychological tests studies memory, intelligence, personality, perception and capability for abstract thinking. PHYSICAL TESTS Blood tests and brain scans may be useful to rule out a physical illness causing psychological symptoms. SOCIAL ASSESSMENT Many patients have social diffculties that can be teased out and helped by a psychiatric social worker. ‘Approved social workers’ have special training in the use of the Mental Health Act, the law that authorises compulsory admissions to psychiatric hospitals and compulsory psychiatric treatments. These social workers also know about all the mental-health services o?ered by local councils and voluntary organisations, and can refer clients to them. The role of some social workers has been widened greatly in recent years by the expansion of community care. OCCUPATIONAL THERAPY ASSESSMENT Mental-health problems causing practical disabilities – for instance, inability to work, cook or look after oneself – can be assessed and helped by occupational therapists.

Treatment The aims of psychiatric treatment are to help sufferers shake o?, or at least cope with, symptoms and to gain or regain an acceptable quality of life. A range of psychological and physical treatments is available.

COUNSELLING This is a widely used ‘talking cure’, particularly in general practice. Counsellors listen to their clients, help them to explore feelings, and help them to ?nd personal and practical solutions to their problems. Counsellors do not probe into clients’ pasts or analyse them. PSYCHOTHERAPY This is the best known ‘talking cure’. The term psychotherapy is a generalisation covering many di?erent concepts. They all started, however, with Sigmund Freud (see FREUDIAN THEORY), the father of modern psychotherapy. Freud was a doctor who discovered that, as well as the conscious thoughts that guide our feelings and actions, there are powerful psychological forces of which we are not usually aware. Applying his theories to his patients’ freely expressed thoughts, Freud was able to cure many illnesses, some of which had been presumed completely physical. This was the beginning of individual analytical psychotherapy, or PSYCHOANALYSIS. Although Freud’s principles underpin all subsequent theories about the psyche, many di?erent schools of thought have emerged and in?uenced psychotherapists (see ADLER; JUNGIAN ANALYSIS; PSYCHOTHERAPY). BEHAVIOUR THERAPY This springs from theories of human behaviour, many of which are based on studies of animals. The therapists, mostly psychologists, help people to look at problematic patterns of behaviour and thought, and to change them. Cognitive therapy is very e?ective, particularly in depression and eating disorders. PHYSICAL TREATMENTS The most widely used physical treatments in psychiatry are drugs. Tranquillising and anxiety-reducing BENZODIAZEPINES like diazepam, well known by its trade name of Valium, were prescribed widely in the 1960s and 70s because they seemed an e?ective and safe substitute for barbiturates. Benzodiazepines are, however, addictive and are now recommended only for short-term relief of anxiety that is severe, disabling, or unacceptably distressing. They are also used for short-term treatment of patients drying out from alcohol.

ANTIDEPRESSANT DRUGS like amitriptyline and ?uoxetine are given to lift depressed mood and to relieve the physical symptoms that sometimes occur in depression, such as insomnia and poor appetite. The side-effects of antidepressants are mostly relatively mild, when recommended doses are not exceeded – although one group, the monoamine oxidase inhibitors, can lead to sudden and dangerous high blood pressure if taken with certain foods.

Manic depression virtually always has to be treated with mood-stabilising drugs. Lithium carbonate is used in acute mania to lower mood and stop psychotic symptoms; it can also be used in severe depression. However lithium’s main use is to prevent relapse in manic depression. Long-term unwanted effects may include kidney and thyroid problems, and short-term problems in the nervous system and kidney may occur if the blood concentration of lithium is too high – therefore it must be monitored by regular blood tests. Carbamazepine, a treatment for EPILEPSY, has also been found to stabilise mood, and also necessitates blood tests.

Antipsychotic drugs, also called neuroleptics, and major tranquillisers are the only e?ective treatments for relieving serious mental illnesses with hallucinations and delusions. They are used mainly in schizophrenia and include the short-acting drugs chlorpromazine and clozapine as well as the long-lasting injections given once every few weeks like ?uphenazine decanoate. In the long term, however, some of the older antipsychotic drugs can cause a brain problem called TARDIVE DYSKINESIA that affects control of movement and is not always reversible. And the antipsychotic drugs’ short-term side-effects such as shaking and sti?ness sometimes have to be counteracted by other drugs called anticholinergic drugs such as procyclidine and benzhexol. Newer antipsychotic drugs such as clozapine do not cause tardive dyskinesia, but clozapine cannot be given as a long-lasting injection and its concentration in the body has to be monitored by regular blood tests to avoid toxicity. OTHER PHYSICAL TREATMENTS The other two physical treatments used in psychiatry are particularly controversial: electroconvulsive therapy (ECT) and psychosurgery. In ECT, which can be life-saving for patients who have severe life-threatening depression, a small electric current is passed through the brain to induce a ?t or seizure. Before the treatment the patient is anaesthetised and given a muscle-relaxing injection that reduces the magnitude of the ?t to a slight twitching or shaking. Scientists do not really understand how ECT works, but it does, for carefully selected patients. Psychosurgery – operating on the brain to alleviate psychiatric illness or di?cult personality traits – is extremely uncommon these days. Stereo-tactic surgery, in which small cuts are made in speci?c brain ?bres under X-ray guidance, has super-seded the more generalised lobotomies of old. The Mental Health Act 1983 ensures that psychosurgery is performed only when the patient has given fully informed consent and a second medical opinion has agreed that it is necessary. For all other psychiatric treatments (except another rare treatment, hormone implantation for reducing the sex drive of sex o?enders), either consent or a second opinion is needed – not both. TREATMENT IN HOSPITAL Psychiatric wards do not look like medical or surgical wards and sta? may not wear uniforms. Patients do not need to be in their beds during the day, so the beds are in separate dormitories. The main part of most wards is a living space with a day room, an activity and television room, quiet rooms, a dining room, and a kitchen. Ward life usually has a certain routine. The day often starts with a community meeting at which patients and nurses discuss issues that affect the whole ward. Patients may go to the occupational therapy department during the day, but there may also be some therapy groups on the ward, such as relaxation training. Patients’ symptoms and problems are assessed continuously during a stay in hospital. When patients seem well enough they are allowed home for trial periods; then discharge can be arranged. Patients are usually followed up in the outpatient clinic at least once.

TREATING PATIENTS WITH ACUTE PSYCHIATRIC ILLNESS Psychiatric emergencies – patients with acute psychiatric illness – may develop from psychological, physical, or practical crises. Any of these crises may need quick professional intervention. Relatives and friends often have to get this urgent help because the sufferer is not ?t enough to do it or, if psychotic, does not recognise the need. First, they should ring the person’s general practitioner. If the general practitioner is not available and help is needed very urgently, relatives or friends should phone the local social-services department and ask for the duty social worker (on 24-hour call). In a dire emergency, the police will know what to do.

Any disturbed adult who threatens his or her own or others’ health and safety and refuses psychiatric help may be moved and detained by law. The Mental Health Act of 1983 authorises emergency assessment and treatment of any person with apparent psychiatric problems that ful?l these criteria.

Although admission to hospital may be the best solution, there are other ways that psychiatric services can respond to emergencies. In some districts there are ‘crisis intervention’ teams of psychiatrists, nurses, and social workers who can visit patients urgently at home (at a GP’s request) and, sometimes, avert unnecessary admission. And research has shown that home treatment for a range of acute psychiatric problems can be e?ective.

LONG-TERM TREATMENT AND COMMUNITY CARE Long-term treatment is often provided by GPs with support and guidance from psychiatric teams. That is ?ne for people whose problems allow them to look after themselves, and for those with plenty of support from family and friends. But some people need much more intensive long-term treatment and many need help with running their daily lives.

Since the 1950s, successive governments have closed the old psychiatric hospitals and have tried to provide as much care as possible outside hospital – in ‘the community’. Community care is e?ective as long as everyone who needs inpatient care, or residential care, can have it. But demand exceeds supply. Research has shown that some homeless people have long-term mental illnesses and have somehow lost touch with psychiatric services. Many more have developed more general long-term health problems, particularly related to alcohol, without ever getting help.

The NHS and Community Care Act 1990, in force since 1993, established a new breed of professionals called care managers to assess people whose long-term illnesses and disabilities make them unable to cope completely independently with life. Care managers are given budgets by local councils to assess people’s needs and to arrange for them tailor-made packages of care, including services like home helps and day centres. But co-ordination between health and social services has sometimes failed – and resources are limited – and the government decided in 1997 to tighten up arrangements and pool community-care budgets.

Since 1992 psychiatrists have had to ensure that people with severe mental illnesses have full programmes of care set up before discharge from hospital, to be overseen by named key workers. And since 1996 psychiatrists have used a new power called Supervised Discharge to ensure that the most vulnerable patients cannot lose touch with mental-health services. There is not, however, any law that allows compulsory treatment in the community.

There is ample evidence that community care can work and that it need not cost more than hospital care. Critics argue, however, that even one tragedy resulting from inadequate care, perhaps a suicide or even a homicide, should reverse the march to community care. And, according to the National Schizophrenia Fellowship, many of the 10–15 homicides a year carried out by people with severe mental illnesses result from inadequate community care.

Further information can be obtained from the Mental Health Act Commission, and from MIND, the National Association for Mental Health. MIND also acts as a campaigning and advice organisation on all aspects of mental health.... mental illness

Oxazepam

A benzodiazpine anxiolytic drug (see BENZODIAZEPINES; ANXIOLYTICS). Like all benzodiazepines, oxazepam should be prescribed with caution at the lowest possible dosage for the shortest possible time, as patients can become dependent on it (see DEPENDENCE). The indication for use is short-term relief of severe anxiety, including panic attacks. Oxazepam has an advantage over many diazepams in being shorter acting, and it can be used for patients with impairment of LIVER function. The drug is inappropriate for treatment of DEPRESSION, obsessional states or PSYCHOSIS (see MENTAL ILLNESS).... oxazepam

Temazepam

A benzodiazepine anxiolytic (see BENZODIAZEPINES; ANXIOLYTICS) derived from diazepam. To be used with care for short-term treatment of insomnia, generally associated with di?culty in falling asleep, frequent nocturnal awakening or early-morning awakening. Temazepam is a relatively quick-acting hypnotic of short duration, so – although there is little hangover the next morning compared with other hypnotics – there may still be some drowsiness and e?ect on skilled tasks such as driving. It should be avoided in elderly people who are at risk of becoming ataxic and so liable to falling and injuring themselves. Temazepam is often abused by drug addicts.... temazepam

Valium

The proprietary name for diazepam, a widely used anxiolytic drug (see ANXIOLYTICS).... valium

Addiction

Dependence on, and craving for, a particular drug, for example alcohol, diazepam (a tranquillizer), or heroin. Reducing or stopping intake of the drug may lead to characteristic physiological or psychological symptoms (see withdrawal syndrome), such as tremor or anxiety. (See also alcohol dependence; drug dependence.)... addiction

Meningitis

In?ammation affecting the membranes of the BRAIN or SPINAL CORD, or usually both. Meningitis may be caused by BACTERIA, viruses (see VIRUS), fungi, malignant cells or blood (after SUBARACHNOID HAEMORRHAGE). The term is, however, usually restricted to in?ammation due to a bacterium or virus. Viral meningitis is normally a mild, self-limiting infection of a few days’ duration; it is the most common cause of meningitis but usually results in complete recovery and requires no speci?c treatment. Usually a less serious infection than the bacterial variety, it does, however, rarely cause associated ENCEPHALITIS, which is a potentially dangerous illness. A range of viruses can cause meningitis, including: ENTEROVIRUSES; those causing MUMPS, INFLUENZA and HERPES SIMPLEX; and HIV.

Bacterial meningitis is life-threatening: in the United Kingdom, 5–10 per cent of children who contract the disease may die. Most cases of acute bacterial meningitis in the UK are caused by two bacteria: Neisseria meningitidis (meningococcus), and Streptococcus pneumoniae (pneumococcus); other bacteria include Haemophilus in?uenzae (a common cause until virtually wiped out by immunisation), Escherichia coli, Mycobacterium tuberculosis (see TUBERCULOSIS), Treponema pallidum (see SYPHILIS) and Staphylococci spp. Of the bacterial infections, meningococcal group B is the type that causes a large number of cases in the UK, while group A is less common.

Bacterial meningitis may occur by spread from nearby infected foci such as the nasopharynx, middle ear, mastoid and sinuses (see EAR, DISEASES OF). Direct infection may be the result of penetrating injuries of the skull from accidents or gunshot wounds. Meningitis may also be a complication of neurosurgery despite careful aseptic precautions. Immuno-compromised patients – those with AIDS or on CYTOTOXIC drugs – are vulnerable to infections.

Spread to contacts may occur in schools and similar communities. Many people harbour the meningococcus without developing meningitis. In recent years small clusters of cases, mainly in schoolchildren and young people at college, have occurred in Britain.

Symptoms include malaise accompanied by fever, severe headache, PHOTOPHOBIA, vomiting, irritability, rigors, drowsiness and neurological disturbances. Neck sti?ness and a positive KERNIG’S SIGN appearing within a few hours of infection are key diagnostic signs. Meningococcal and pneumococcal meningitis may co-exist with SEPTICAEMIA, a much more serious condition in terms of death rate or organ damage and which constitutes a grave emergency demanding rapid treatment.

Diagnosis and treatment are urgent and, if bacterial meningitis is suspected, antibiotic treatment should be started even before laboratory con?rmation of the infection. Analysis of the CEREBROSPINAL FLUID (CSF) by means of a LUMBAR PUNCTURE is an essential step in diagnosis, except in patients for whom the test would be dangerous as they have signs of raised intracranial pressure. The CSF is clear or turbid in viral meningitis, turbid or viscous in tuberculous infection and turbulent or purulent when meningococci or staphylococci are the infective agents. Cell counts and biochemical make-up of the CSF are other diagnostic pointers. Serological tests are done to identify possible syphilitic infection, which is now rare in Britain.

Patients with suspected meningitis should be admitted to hospital quickly. General pracitioners are encouraged to give a dose of intramuscular penicillin before sending the child to hospital. Treatment in hospital is usually with a cephalosporin, such as ceftazidime or ceftriaxone. Once the sensitivity of the organism is known as a result of laboratory studies on CSF and blood, this may be changed to penicillin or, in the case of H. in?uenzae, to amoxicillin. Local infections such as SINUSITIS or middle-ear infection require treatment, and appropriate surgery for skull fractures or meningeal tears should be carried out as necessary. Tuberculous meningitis is treated for at least nine months with anti-tuberculous drugs (see TUBERCULOSIS). If bacterial meningitis causes CONVULSIONS, these can be controlled with diazepam (see TRANQUILLISERS; BENZODIAZEPINES) and ANALGESICS will be required for the severe headache.

Coexisting septicaemia may require full intensive care with close attention to intravenous ?uid and electrolyte balance, control of blood clotting and blood pressure.

Treatment of close contacts such as family, school friends, medical and nursing sta? is recommended if the patient has H. in?uenzae or N. meningitidis: RIFAMPICIN provides e?ective prophylaxis. Contacts of patients with pneumococcal infection do not need preventive treatment. Vaccines for meningococcal meningitis may be given to family members in small epidemics and to any contacts who are especially at risk such as infants, the elderly and immuno-compromised individuals.

The outlook for a patient with bacterial meningitis depends upon age – the young and old are vulnerable; speed of onset – sudden onset worsens the prognosis; and how quickly treatment is started – hence the urgency of diagnosis and admission to hospital. Recent research has shown that children who suffer meningitis in their ?rst year of life are ten times more likely to develop moderate or severe disability by the age of ?ve than contemporaries who have not been infected. (See British Medical Journal, 8 September 2001, page 523.)

Prevention One type of bacterial meningitis, that caused by Haemophilus, has been largely controlled by IMMUNISATION; meningococcal C vaccine has largely prevented this type of the disease in the UK. So far, no vaccine against group B has been developed, but research continues. Information on meningitis can be obtained from the Meningitis Trust and the Meningitis Research Foundation.... meningitis

Hiccup

A sudden, involuntary contraction of the diaphragm followed by rapid closure of the vocal cords.

Most attacks of hiccups last only a few minutes, and are not medically significant.

Rarely, they may be due to a condition, such as pneumonia or pancreatitis, that causes irritation of the diaphragm or phrenic nerves.

Chlorpromazine, haloperidol, or diazepam may be prescribed for frequent, prolonged attacks.... hiccup

Benzodiazepines

pl. n. a group of pharmacologically active compounds used as *anxiolytics and hypnotics. The group includes *chlordiazepoxide, *diazepam, *oxazepam, and *temazepam.... benzodiazepines

Muscle Relaxants

These drugs produce partial or complete paralysis of skeletal muscle (see under MUSCLE – Structure of muscle). Drugs in clinical use are all reversible and are used to help insert a breathing tube into the TRACHEA (endotracheal tube) during general ANAESTHESIA and ARTIFICIAL VENTILATION OF THE LUNGS. They may be broadly divided into depolarising and nondepolarising muscle relaxants. Depolarising muscle relaxants act by binding to acetylcholine receptors at the motor end-plate where nerves are attached to muscle cells, and producing a more prolonged depolarisation than acetylcholine, which results in initial muscle fasciculation (overactivity) and then ?accid paralysis of the muscle. The only commonly used depolarising drug is succinylcholine which has a rapid onset of action and lasts approximately three minutes. Non-depolarising muscle relaxants bind to the acetylcholine receptors, preventing acetylcholine from gaining access to them. They have a slower onset time and longer duration than depolarisers, although this varies widely between di?erent drugs. They are competitive antagonists and they may be reversed by increasing the concentration of acetylcholine at the motor end-plate using an anticholinesterase agent such as neostigmine. These drugs are broken down in the liver and excreted through the kidney, and their action will be prolonged in liver and renal failure. Other uses include the relief of skeletal muscle spasms in TETANUS, PARKINSONISM and spastic disorders. The drugs dantrolene and diazepam are used in these circumstances.... muscle relaxants

Paraldehyde

A clear, colourless liquid with a penetrating ethereal (see ETHER) odour, paraldehyde may be given by mouth, rectally, or occasionally in intramuscular injection. The drug’s prime use is as a hypnotic (see HYPNOTICS) in mentally unstable patients. It is also indicated as an anticonvulsant in STATUS EPILEPTICUS (after initial intravenous DIAZEPAM) and in TETANUS. Its unpleasant taste restricts its use, but this has the advantage that it usually prevents the patient from becoming an addict.

Caution is needed when treating patients with bronchopulmonary disease or liver impairment; and intramuscular injection near the sciatic nerve should be avoided, as it may cause severe CAUSALGIA. Adverse effects include rashes; pain and sterile ABSCESS after intramuscular injection; rectal irritation after ENEMA.... paraldehyde

Tranquillisers

A tranquilliser is a popular name for a drug which induces a mental state free from agitation and anxiety, and renders the patient calm. Tranquillisers are classi?ed as major and minor. The former are used to treat psychotic illness such as SCHIZOPHRENIA; the latter are sedatives used to treat anxiety and emotional upsets (see NEUROSIS) and are called antianxiety drugs or ANXIOLYTICS. Major tranquillisers or antipsychotic drugs are given to patients with psychotic disorders which disrupt their normal lives (see PSYCHOSIS). They do not cure the patient, but do help to control his or her symptoms so that the person can live in the community and be admitted to hospital only for acute episodes. The drug chosen depends upon the type of illness and needs of a particular patient as well as the likely adverse effects. Antipsychotic drugs modify the transmission of nerve-signals by making brain cells less sensitive to the excitatory neurotransmitter chemical called DOPAMINE. Among the antipsychotic tranquillisers are CHLORPROMAZINE, HALOPERIDOL, CLOZAPINE and ?upenthixol.

Anxiety is a consequence of too much STRESS and may occur without being serious enough to need treatment. Clinically it arises when the balance between certain chemicals in the brain is disturbed: this increases activity in the sympathetic system, thus provoking physical symptoms such as breathlessness, tachycardia, headaches and indigestion. Anxiolytics help to alleviate these symptoms but do not necessarily cure the underlying cause. Two main classes of drug relieve anxiety: BENZODIAZEPINES and beta blockers (see BETA-ADRENOCEPTORBLOCKING DRUGS). The latter, which include atenolol and propanolol, reduce the physical symptoms such as tachycardia and are useful in circumstances – for example, examinations – known to cause anxiety attacks. They block the action of NORADRENALINE, a key chemical of the sympathetic nervous system. Benzodiazepines depress activity in that part of the brain controlling emotion by stimulating the action of a chemical called gammaaminobutyric acid (GABA). Among the benzodiazepines are chlordiazepoxide and diazepam. (See also MENTAL ILLNESS.)... tranquillisers

Tetanus

Also called LOCKJAW, this is a bacterial infection of the nervous system. Increased excitability of the SPINAL CORD results in painful and prolonged spasms of the voluntary muscles throughout the body, rapidly leading to death unless treated.

Causes The disease is caused by the bacillus Clostridium tetani, found generally in earth and dust and especially in places where animal manure is collected. Infection usually follows a wound, especially a deeply punctured or gunshot wound, with the presence of some foreign body. It is a hazard in war and also among farmers, gardeners and those in the construction industry. The bacillus develops a toxin in the wound, which is absorbed through the motor nerves into the spinal cord where it renders the nerves excitable and acutely sensitive to mild stimuli.

Symptoms Most commonly appearing within four to ?ve days of the wound, the patient’s symptoms may be delayed for several weeks – by which time the wound may have healed. Initially there is muscle sti?ness around the wound followed by sti?ness around the jaw, leading to lockjaw, or trismus. This extends to the muscles of the neck, back, chest, abdomen, and limbs, leading to strange, often changing, contorted postures, accompanied by frequent seizures – often provoked by quite minor stimuli such as a sudden noise. The patient’s breathing may be seriously affected, in severe cases leading to ASPHYXIA; the temperature may rise sharply, often with sweating; and severe pain is common. Mental clarity is characteristic adding to the patient’s anxiety. In severe infections death may be from asphyxia, PNEUMONIA, or general exhaustion. More commonly, the disease takes a chronic course, leading to gradual recovery. Outcome depends on several factors, chie?y the patient’s immune status and age, and early administration of appropriate treatment.

Tetanus may occur in newborn babies, particularly when birth takes place in an unhygienic environment. It is particularly common in the tropics and developing countries, with a high mortality rate. Local tetanus is a rare manifestation, in which only muscles around the wound are affected, though sti?ness may last for several months. STRYCHNINE poisoning and RABIES, although similar in some respects to tetanus, may be easily distinguished by taking a good history.

Prevention and treatment The incidence of tetanus in the United Kingdom has been almost abolished by the introduction of tetanus vaccine (see IMMUNISATION). Children are routinely immunised at two, three and four months of age, and boosters are given later in life to at-risk workers, or those travelling to tropical parts.

Treatment should be started as soon as possible after sustaining a potentially dangerous wound. An intravenous injection of antitoxin should be given immediately, the wound thoroughly cleaned and PENICILLIN administered. Expert nursing is most important. Spasms may be minimised by reducing unexpected stimuli, and diazepam (see BENZODIAZEPINES; TRANQUILLISERS) is helpful. Intravenous feeding should be started immediately if the patient cannot swallow. Aspiration of bronchial secretions and antibiotic treatment of pneumonia may be necessary.... tetanus

Valeriana Officinalis

Linn.

Family: Valerianaceae.

Habitat: Native to Eurasia. (V officinalis auct. non Linn. is found in Kashmir at Sonamarg at 2,4002,700 m)

English: Valerian, Garden Heliotrope, Common Valerian.

Ayurvedic: Tagara, Nata. Baalaka (syn. Udichya, Jala, Barhishtha) is also equated with Valeriana sp.

Folk: Sugandhabaalaa, taggar.

Action: Tranquillizer, hypnotic, a natural relaxant to higher nerve centres. Used for nervous tension, sleeplessness, restlessness, palpitation, tension, headache, migraine, menstrual pain, intestinal cramps, bronchial spasm.

Key application: Internally for restlessness and sleeping disorders based on nervous conditions (German Commission E). (See Expanded Commission E, ESCOP and WHO monographs.)

Constituents of the root include val- trates, didrovaltrates and isovalerates. Other constituents include 0.4-1.4% monoterpenes and sesquiterpenes, caf- feic, gamma-aminobutyric (GABA) and chlorogenic acids, beta-sitosterol, methyl, 2-pyrrolketone, choline, tannins, gums alkaloids and resin. (Expanded Commission E Monographs.)

The volatile oil (0.5-2%) contains bornyl acetate and bornyl isovalerate as the principal components. Other constituents include beta-caryophyllene, valeranone, valerenal, valerenic acid and other sesquiterpenoids and mono- terpenes.

The co-occurrence of three cyclo- pentane-sesquiterpenoids (valerenic acid, acetoxyvalerenic acid and valere- nal) is confined to Valeriana officinalis L. and permits its distinction from V edulis and V. Wallichii. (WHO.)

The important active compounds of valerian are the valepotriates (iridoid molecules) and valeric acid. Originally it was thought that valepotriates were responsible for the herbs sedative effect, but, later on, an aqueous extract of the root has also been shown to have a sedative effect. Since valepotriates are not soluble in water, it was concluded that valerenic acid is also the chemical factor responsible for the sedative effect of the herb. Most commercial extracts in Western herbal are water-soluble extracts standardized for valerenic acids.

Large doses ofvalepotriates from the herb decreased benzodiazepines and diazepam withdrawl symptoms in rats. At low doses valerian enhances binding of flunitrazepam, but at high doses it inhibits binding of the drug. Valerenic acid inhibits breakdown of GABA, and hydroxypinoresinol binds to benzodi- azepine receptor. (Sharon M. Herr.)

The safety of valepotriates has been questioned.

Currently valerian is an approved over-the-counter medicine in Germany, Belgium, France, Switzerland and Italy. (The British Herbal Compendium.)

See Valeriana dubia Bunge, syn. V. officinalis auct. non Linn., known as Common Valerian.... valeriana officinalis

Benzodiazepine Drugs

A group of drugs given for short periods as sleeping drugs for insomnia and to control the symptoms of anxiety or stress (see tranquillizer drugs). Common benzodiazepines include diazepam, which is used as a tranquillizer, and nitrazepam, which is sometimes used for insomnia. Benzodiazepines are also used in the management of alcohol withdrawal and in the control of epilepsy.

Minor adverse effects of benzodiazepines include daytime drowsiness, dizziness, and forgetfulness. Unsteadiness and slowed reactions may also occur. Regular users may become psychologically and physically dependent; for this reason, the drugs are usually given for courses of 2–3 weeks or less. When the drugs are stopped suddenly, withdrawal symptoms, such as anxiety, restlessness, and nightmares may occur. Benzodiazepine drugs are sometimes abused for their sedative effect.... benzodiazepine drugs

Withdrawal Syndrome

Unpleasant mental and physical symptoms experienced when a person stops using a drug on which he or she is dependent (see drug dependence). Withdrawal syndrome most commonly occurs in those with alcohol dependence or dependence on opioids, in smokers, and in people addicted to tranquillizers, amfetamines, cocaine, marijuana, and caffeine.

Alcohol withdrawal symptoms start 6–8 hours after cessation of intake and may last up to 7 days. They include trembling of the hands, nausea, vomiting, sweating, cramps, anxiety, and, sometimes, seizures. (See also confusion, delirium tremens, and hallucinations.)

Opioid withdrawal symptoms start after 8–12 hours and may last for 7–10 days. Symptoms include restlessness, sweating, runny eyes and nose, yawning, diarrhoea, vomiting, abdominal cramps, dilated pupils, loss of appetite, irritability, weakness, tremor, and depression.

Withdrawal symptoms from barbiturate drugs and meprobamate start after 12–24 hours, beginning with tremor, anxiety, restlessness, and weakness, sometimes followed by delirium, hallucinations, and, occasionally, seizures. A period of prolonged sleep occurs 3–8 days after onset. Withdrawal from benzodiazepine drugs may begin much more slowly and can be life-threatening.

Withdrawal symptoms from nicotine develop gradually over 24–48 hours and include irritability, concentration problems, frustration, headaches, and anxiety. Discontinuation of cocaine or amfetamines results in extreme tiredness, lethargy, and dizziness. Cocaine withdrawal may also lead to tremor, severe depression, and sweating.

Withdrawal symptoms from marijuana include tremor, nausea, vomiting, diarrhoea, sweating, irritability, and sleep problems. Caffeine withdrawal may lead to tiredness, headaches, and irritability.

Severe withdrawal syndromes require medical treatment.

Symptoms may be suppressed by giving the patient small quantities of the drug he or she had been taking.

More commonly, a substitute drug is given, such as methadone for opioid drugs or diazepam for alcohol.

The dose of the drug is then gradually reduced.... withdrawal syndrome

Blood-brain Barrier

the mechanism that controls the passage of molecules from the blood into the cerebrospinal fluid and the tissue spaces surrounding the cells of the brain. The endothelial cells lining the walls of the brain capillaries are more tightly joined together at their edges than those lining capillaries supplying other parts of the body. This allows the passage of solutions and fat-soluble compounds but excludes particles and large molecules. The importance of the blood-brain barrier is that it protects the brain from the effect of many substances harmful to it. A disadvantage, however, is that many useful drugs pass only in small amounts into the brain, and much larger doses may have to be given than normal. Brain cancer, for example, is relatively insensitive to chemotherapy, although drugs such as diazepam, alcohol, and fat-soluble general anaesthetics pass readily and quickly to the brain cells.... blood-brain barrier

Muscle Relaxant

an agent that reduces tension in voluntary muscles. Drugs such as *baclofen, *dantrolene, and *diazepam are used to relieve skeletal muscular spasms in various spastic conditions, parkinsonism, and tetanus. The drugs used to relax voluntary muscles during the administration of anaesthetics in surgical operations act by blocking the transmission of impulses at neuromuscular junctions. Nondepolarizing muscle relaxants, e.g. *atracurium besilate, cisatracurium, pancuronium, and rocuronium, bind to receptor sites normally occupied by acetylcholine; depolarizing muscle relaxants, e.g. *suxamethonium, mimic the action of acetylcholine but *depolarization is prolonged.... muscle relaxant



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