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n. a fluid that circulates throughout the body, via the arteries and veins, providing a vehicle by which an immense variety of different substances are transported between the various organs and tissues. It is composed of *blood cells, which are suspended in a liquid medium, the *plasma. An average individual has approximately 70 ml of blood per kilogram body weight (about 5 litres in an average adult male). See Appendix 2.
Blood consists of cellular components suspended in plasma. It circulates through the blood vessels, carrying oxygen and nutrients to the organs and removing carbon dioxide and other waste products for excretion. In addition, it is the vehicle by which hormones and other humoral transmitters reach their sites of action.
Composition The cellular components are red cells or corpuscles (ERYTHROCYTES), white cells (LEUCOCYTES and lymphocytes – see LYMPHOCYTE), and platelets.
The red cells are biconcave discs with a diameter of 7.5µm. They contain haemoglobin
– an iron-containing porphyrin compound, which takes up oxygen in the lungs and releases it to the tissue.
The white cells are of various types, named according to their appearance. They can leave the circulation to wander through the tissues. They are involved in combating infection, wound healing, and rejection of foreign bodies. Pus consists of the bodies of dead white cells.
Platelets are the smallest cellular components and play an important role in blood clotting (see COAGULATION).
Erythrocytes are produced by the bone marrow in adults and have a life span of about 120 days. White cells are produced by the bone
marrow and lymphoid tissue. Plasma consists of water, ELECTROLYTES and plasma proteins; it comprises 48–58 per cent of blood volume. Plasma proteins are produced mainly by the liver and by certain types of white cells. Blood volume and electrolyte composition are closely regulated by complex mechanisms involving the KIDNEYS, ADRENAL GLANDS and HYPOTHALAMUS.
The red fluid that circulates in the body’s veins, arteries, and capillaries. Blood is pumped by the heart via the arteries to the lungs and all other tissues and is then returned to the heart in veins (see circulatory system). Blood is the body’s transport system and plays an important role in the defence against infection. An average adult has about 5 litres of blood.
Almost half of the volume of blood consists of blood cells; these include red blood cells (erythrocytes), which carry oxygen to tissues; white blood cells (leukocytes), which fight infection; and platelets (thrombocytes), which are involved in blood clotting. The remainder of the blood volume is a watery, strawcoloured fluid called plasma, which contains dissolved proteins, sugars, fats, salts, and minerals. Nutrients are transported in the blood to the tissues after absorption from the intestinal tract or after release from storage depots such as the liver. Waste products, including urea and bilirubin are carried in the plasma to the kidneys and liver respectively.
Plasma proteins include fibrinogen; which is involved in blood clotting; immunoglobulins (also called antibodies) and complement, which are part of the immune system; and albumin. Hormones are also transported in the blood to their target organs.
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